PMID- 19303811
OWN - NLM
STAT- MEDLINE
DCOM- 20091217
LR  - 20131121
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 10
IP  - 8
DP  - 2009 Sep
TI  - Combined adaptive servo-ventilation and automatic positive airway pressure 
      (anticyclic modulated ventilation) in co-existing obstructive and central sleep 
      apnea syndrome and periodic breathing.
PG  - 898-903
LID - 10.1016/j.sleep.2008.09.017 [doi]
AB  - BACKGROUND: The co-existence of obstructive and central sleep apnea/hypopnea 
      syndrome (OSAS) and periodic breathing is common in patients with and without 
      underlying heart diseases. While automatic continuous positive airway pressure 
      (APAP) has proven to effectively treat OSAS, the adaptive servo-ventilation (ASV) 
      sufficiently improves periodic breathing. This is the first trial on a device 
      which combines both treatment modes. METHODS: Pilot study on a two-week treatment 
      in patients with co-existing obstructive and central and periodic breathing 
      disturbances during sleep. Twelve consecutive patients (9 male, 3 female, age 
      56.9+/-10.6 years, BMI 32.4+/-5.5 kg/m(2)) were treated with a new algorithm 
      which combines APAP and ASV (also called anticyclic modulated ventilation (ACMV), 
      SOMNOventCR, Weinmann, Hamburg, Germany). Seven suffered from arterial 
      hypertension, coronary heart disease and mitral regurgitation, none from 
      congestive heart failure. RESULTS: The total apnea-hypopnea index (AHI) improved 
      from 43.8+/-24.0/h to 2.1+/-2.4 (p<0.01), the obstructive AHI from 12.8+/-14.3/h 
      to 0.3+/-0.6/h (p<0.01) and the central AHI from 31.0+/-17.5/h to 1.7+/-2.0/h 
      (p<0.01). Moreover, there was a significant improvement in the total number of 
      arousals, respiratory induced arousals, oxygen saturation and sleep profile. 
      CONCLUSION: The algorithm combining automatic continuous positive airway pressure 
      (CPAP) and ASV normalizes all types of co-existing obstructive and central 
      apnea/hypopnea and periodic breathing.
FAU - Randerath, Winfried J
AU  - Randerath WJ
AD  - Institute of Pneumology at the University Witten/Herdecke, Clinic for Pneumology 
      and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien 
      Hospital, Aufderhoherstrasse 169-175, Solingen, Germany. 
      randerath@klinik-bethanien.de
FAU - Galetke, Wolfgang
AU  - Galetke W
FAU - Kenter, Marlene
AU  - Kenter M
FAU - Richter, Kerstin
AU  - Richter K
FAU - Schafer, Thorsten
AU  - Schafer T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20090320
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Cheyne-Stokes Respiration/therapy
MH  - Continuous Positive Airway Pressure/*instrumentation/*methods
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Inhalation
MH  - Male
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Pilot Projects
MH  - Polysomnography
MH  - Sleep Apnea Syndromes/*therapy
MH  - Sleep Apnea, Obstructive/*therapy
MH  - Treatment Outcome
EDAT- 2009/03/24 09:00
MHDA- 2009/12/18 06:00
CRDT- 2009/03/24 09:00
PHST- 2008/06/22 00:00 [received]
PHST- 2008/08/13 00:00 [revised]
PHST- 2008/09/02 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/12/18 06:00 [medline]
AID - S1389-9457(08)00370-5 [pii]
AID - 10.1016/j.sleep.2008.09.017 [doi]
PST - ppublish
SO  - Sleep Med. 2009 Sep;10(8):898-903. doi: 10.1016/j.sleep.2008.09.017. Epub 2009 
      Mar 20.