PMID- 19303972
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20220317
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 58
IP  - 4
DP  - 2009 Apr
TI  - Beneficial effects of designed dietary fatty acid compositions on lipids in 
      triacylglycerol-rich lipoproteins among Chinese patients with type 2 diabetes 
      mellitus.
PG  - 510-8
LID - 10.1016/j.metabol.2008.11.010 [doi]
AB  - Elevated levels of postprandial triacylglycerol-rich lipoproteins (ppTRLs) are 
      atherogenic. Patients with type 2 diabetes mellitus (T2DM) have exaggerated 
      postprandial lipemia associated with elevation or prolonged residence of ppTRL 
      remnants. We examined whether dietary fatty acid compositions (DFACs) decrease 
      atherogenic lipid profiles in ppTRL subfractions in T2DM Chinese patients. A 
      single-blind randomized controlled trial was conducted among 28 T2DM patients. 
      Patients consumed 1 of 3 standardized DFAC-specific fat meals: equidominant 
      (1:1:1), polyunsaturated fatty acid (PUFA)-dominant (PUFA-D, 1:1.7:2.3), or 
      monounsaturated fatty acid (MUFA)-dominant (MUFA-D, 1:1.7:1.2) meals. Numbers in 
      parenthesis, respectively, represent the ratio of saturated fatty acids, MUFA, 
      and PUFA to saturated fatty acids. The MUFA-D meal was the control. 
      Triacylglycerol and cholesterol levels were measured in Svedberg flotation rate 
      (S(f)) greater than 400, S(f) 60 to 400, S(f) 20 to 60, and S(f) 12 to 20 ppTRL 
      subfractions at fasting (0 hour) and 2, 4, and 6 hours after the consumption of 
      the fat meals. Effects of DFACs on mean concentrations of triacylglycerols and 
      cholesterol averaged over 0, 2, 4, and 6 hours in ppTRL subfractions were 
      assessed using linear mixed models. Stability and robustness were validated with 
      1000 bootstrap replicates. Contrasted to the control, equidominant meal reduced 
      6-hour average triacylglycerol levels in S(f) greater than 400 (P = .002, 
      bootstrap P < .05) and S(f) 20 to 60 (P = .02, bootstrap P < .05) subfractions, 
      and decreased average S(f) 20 to 60 cholesterol (P = .04, bootstrap P < .05); 
      PUFA-D decreased S(f) greater than 400 average triacylglycerol levels (P = .09, 
      bootstrap P < .05). Bootstrap samples suggested that PUFA-D decreased average 
      S(f) 20 to 60 cholesterol levels (bootstrap P < .05). Therefore, modifying DFACs 
      attenuates the atherogenic lipid profile of ppTRLs in T2DM patients; but 
      increasing PUFA ratio may be more feasible.
FAU - Dai, Jun
AU  - Dai J
AD  - Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA. 
      jdai@indiana.edu
FAU - Su, Yi-Xiang
AU  - Su YX
FAU - Bartell, Scott
AU  - Bartell S
FAU - Le, Ngoc-Anh
AU  - Le NA
FAU - Ling, Wen-Hua
AU  - Ling WH
FAU - Liang, Yi-Quan
AU  - Liang YQ
FAU - Gao, Ling
AU  - Gao L
FAU - Wu, Hai-Yan
AU  - Wu HY
FAU - Veledar, Emir
AU  - Veledar E
FAU - Vaccarino, Viola
AU  - Vaccarino V
LA  - eng
SI  - ClinicalTrials.gov/NCT00467168
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - China
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Dietary Fats/*therapeutic use
MH  - Fatty Acids/chemistry/*therapeutic use
MH  - Female
MH  - Humans
MH  - *Lipid Metabolism
MH  - Lipoproteins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/*metabolism
EDAT- 2009/03/24 09:00
MHDA- 2009/04/21 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/06/23 00:00 [received]
PHST- 2008/11/24 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
AID - S0026-0495(08)00428-9 [pii]
AID - 10.1016/j.metabol.2008.11.010 [doi]
PST - ppublish
SO  - Metabolism. 2009 Apr;58(4):510-8. doi: 10.1016/j.metabol.2008.11.010.