PMID- 19303977
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20220318
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 58
IP  - 4
DP  - 2009 Apr
TI  - Serum levels of angiopoietin-related growth factor in diabetes mellitus and 
      chronic hemodialysis.
PG  - 547-51
LID - 10.1016/j.metabol.2008.11.016 [doi]
AB  - Angiopoietin-related growth factor (AGF) was recently introduced as a novel 
      liver-derived protein that antagonizes obesity and insulin resistance. In the 
      current study, we investigated circulating AGF levels in relation to renal 
      function and type 2 diabetes mellitus (T2DM). Angiopoietin-related growth factor 
      was determined by enzyme-linked immunosorbent assay in subjects with a glomerular 
      filtration rate greater than 50 mL/min (n = 60, 30 diabetic and 30 nondiabetic) 
      and in patients on chronic hemodialysis (CD; n = 60, 32 diabetic and 28 
      nondiabetic). Furthermore, AGF was correlated to clinical and biochemical 
      measures of renal function, glucose and lipid metabolism, as well as 
      inflammation. Median serum AGF levels were significantly lower in CD patients 
      (125.9 +/- 96.3 microg/L) as compared with subjects with a glomerular filtration 
      rate greater than 50 mL/min (164.0 +/- 95.4 microg/L) (P < .05). Furthermore, AGF 
      serum levels were significantly increased in diabetic patients (161.7 +/- 114.2 
      microg/L) as compared with nondiabetic subjects (123.0 +/- 88.2 microg/L) (P < 
      .01). Moreover, CD negatively and T2DM positively predicted AGF concentrations in 
      multiple regression analysis. In addition, fasting serum glucose was 
      independently and positively correlated with circulating AGF in all patients and 
      controls. Our results suggest that renal dysfunction is negatively and T2DM is 
      positively associated with AGF serum levels. Further studies are needed to better 
      elucidate the physiologic significance of circulating AGF in human disease.
FAU - Ebert, Thomas
AU  - Ebert T
AD  - Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, 
      Germany.
FAU - Bachmann, Anette
AU  - Bachmann A
FAU - Lossner, Ulrike
AU  - Lossner U
FAU - Kratzsch, Jurgen
AU  - Kratzsch J
FAU - Bluher, Matthias
AU  - Bluher M
FAU - Stumvoll, Michael
AU  - Stumvoll M
FAU - Fasshauer, Mathias
AU  - Fasshauer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (ANGPTL6 protein, human)
RN  - 0 (Angiopoietin-Like Protein 6)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Angiopoietins)
SB  - IM
MH  - Aged
MH  - Angiopoietin-Like Protein 6
MH  - Angiopoietin-like Proteins
MH  - Angiopoietins/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Renal Dialysis
EDAT- 2009/03/24 09:00
MHDA- 2009/04/21 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/07/03 00:00 [received]
PHST- 2008/11/18 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
AID - S0026-0495(08)00434-4 [pii]
AID - 10.1016/j.metabol.2008.11.016 [doi]
PST - ppublish
SO  - Metabolism. 2009 Apr;58(4):547-51. doi: 10.1016/j.metabol.2008.11.016.