PMID- 19303978
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20220409
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 58
IP  - 4
DP  - 2009 Apr
TI  - Cold exposure increases adiponectin levels in men.
PG  - 552-9
LID - 10.1016/j.metabol.2008.11.017 [doi]
AB  - Sympathetic nerve activation is recognized at the adipose tissue level during 
      cold exposure. Adiponectin is a key protein produced by adipose tissue, but its 
      acute modulation remains unknown in humans exposed to cold. The aim of this study 
      were (1) to examine the acute effects of cold exposure on circulating adiponectin 
      and (2) to determine whether the changes are modulated by (a) an acute glucose 
      ingestion as well as (b) a short-term modulation in carbohydrate (CHO) 
      availability. Using a random crossover design, 6 healthy men were exposed to cold 
      for 120 minutes with ingestion of beverages containing low (Control, 0.04 g/min) 
      or high (High, 0.8 g/min) amounts of glucose during the course of the experiment 
      (study 1). In study 2, 6 healthy men were exposed twice to cold for 120 minutes 
      after equicaloric low-CHO diet and exercise and high-CHO diet without exercise. 
      Plasma adiponectin concentrations were quantified before and during cold 
      exposure. In study 1, adiponectin levels did not change during High, whereas a 
      20% rise was observed during Control (condition x time interaction, P = .06). In 
      study 2, adiponectin levels increased by approximately 70% during cold exposure 
      after both low- and high-CHO diets (effect of time, P < .05). A 120-minute period 
      of cold exposure is accompanied by a significant increase in adiponectin levels 
      in young healthy men. The rise in adiponectin levels observed during shivering is 
      inhibited with glucose ingestion but not after diets varying in CHO content.
FAU - Imbeault, Pascal
AU  - Imbeault P
AD  - Behavioural and Metabolic Research Unit (Montfort Hospital), School of Human 
      Kinetics, Faculty of Health Sciences, University of Ottawa, Ontario, Canada K1N 
      6N5. imbeault@uottawa.ca
FAU - Depault, Isabelle
AU  - Depault I
FAU - Haman, Francois
AU  - Haman F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Adiponectin)
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Body Temperature
MH  - *Cold Temperature
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Humans
MH  - Male
EDAT- 2009/03/24 09:00
MHDA- 2009/04/21 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/07/09 00:00 [received]
PHST- 2008/11/04 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
AID - S0026-0495(08)00435-6 [pii]
AID - 10.1016/j.metabol.2008.11.017 [doi]
PST - ppublish
SO  - Metabolism. 2009 Apr;58(4):552-9. doi: 10.1016/j.metabol.2008.11.017.