PMID- 19304328
OWN - NLM
STAT- MEDLINE
DCOM- 20090706
LR  - 20171116
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 210
IP  - 1-2
DP  - 2009 May 29
TI  - KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis.
PG  - 113-5
LID - 10.1016/j.jneuroim.2009.03.001 [doi]
AB  - Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of 
      multiple sclerosis (MS). This proposed immunoregulatory pathway involves already 
      established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and 
      interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell 
      effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in 
      a study population of 763 cases and 967 controls. Whereas 26% of the study 
      population has a genotype corresponding to a lack of any functional 
      membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane 
      alleles with susceptibility to MS was observed.
FAU - Goris, An
AU  - Goris A
AD  - Katholieke Universiteit Leuven, Belgium. An.Goris@med.kuleuven.be
FAU - Dobosi, Rita
AU  - Dobosi R
FAU - Boonen, Steven
AU  - Boonen S
FAU - Nagels, Guy
AU  - Nagels G
FAU - Dubois, Benedicte
AU  - Dubois B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CD56 Antigen)
RN  - 0 (Genetic Markers)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (Receptors, KIR2DL4)
SB  - IM
MH  - Adult
MH  - CD56 Antigen/metabolism
MH  - Cell Membrane/genetics/immunology/metabolism
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*genetics/immunology/physiopathology
MH  - Polymorphism, Genetic/*genetics
MH  - Predictive Value of Tests
MH  - Receptors, KIR2DL4/*genetics
MH  - Young Adult
EDAT- 2009/03/24 09:00
MHDA- 2009/07/07 09:00
CRDT- 2009/03/24 09:00
PHST- 2008/11/28 00:00 [received]
PHST- 2009/03/02 00:00 [revised]
PHST- 2009/03/02 00:00 [accepted]
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/07/07 09:00 [medline]
AID - S0165-5728(09)00092-7 [pii]
AID - 10.1016/j.jneuroim.2009.03.001 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2009 May 29;210(1-2):113-5. doi: 10.1016/j.jneuroim.2009.03.001.