PMID- 19304780
OWN - NLM
STAT- MEDLINE
DCOM- 20090708
LR  - 20221207
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 18
IP  - 12
DP  - 2009 Jun 15
TI  - Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to 
      blood pressure determination in two European populations.
PG  - 2288-96
LID - 10.1093/hmg/ddp135 [doi]
AB  - Hypertension is a complex disease that affects a large proportion of adult 
      population. Although approximately half of the inter-individual variance in blood 
      pressure (BP) level is heritable, identification of genes responsible for its 
      regulation has remained challenging. Genome-wide association study (GWAS) is a 
      novel approach to search for genetic variants contributing to complex diseases. 
      We conducted GWAS for three BP traits [systolic and diastolic blood pressure (SBP 
      and DBP); hypertension (HYP)] in the Kooperative Gesundheitsforschung in der 
      Region Augsburg (KORA) S3 cohort (n = 1644) recruited from general population in 
      Southern Germany. GWAS with 395,912 single nucleotide polymorphisms (SNPs) 
      identified an association between BP traits and a common variant rs11646213 (T/A) 
      upstream of the CDH13 gene at 16q23.3. The initial associations with HYP and DBP 
      were confirmed in two other European population-based cohorts: KORA S4 (Germans) 
      and HYPEST (Estonians). The associations between rs11646213 and three BP traits 
      were replicated in combined analyses (dominant model: DBP, P = 5.55 x 10(-5), 
      effect -1.40 mmHg; SBP, P = 0.007, effect -1.56 mmHg; HYP, P = 5.30 x 10(-8), OR 
      = 0.67). Carriers of the minor allele A had a decreased risk of hypertension. A 
      non-significant trend for association was also detected with severe family based 
      hypertension in the BRIGHT sample (British). The novel susceptibility locus, 
      CDH13, encodes for an adhesion glycoprotein T-cadherin, a regulator of vascular 
      wall remodeling and angiogenesis. Its function is compatible with the BP biology 
      and may improve the understanding of the pathogenesis of hypertension.
FAU - Org, Elin
AU  - Org E
AD  - Department of Biotechnology, Institute of Molecular and Cell Biology, University 
      of Tartu, Riia 23, 51010 Tartu, Estonia.
FAU - Eyheramendy, Susana
AU  - Eyheramendy S
FAU - Juhanson, Peeter
AU  - Juhanson P
FAU - Gieger, Christian
AU  - Gieger C
FAU - Lichtner, Peter
AU  - Lichtner P
FAU - Klopp, Norman
AU  - Klopp N
FAU - Veldre, Gudrun
AU  - Veldre G
FAU - Doring, Angela
AU  - Doring A
FAU - Viigimaa, Margus
AU  - Viigimaa M
FAU - Sober, Siim
AU  - Sober S
FAU - Tomberg, Kart
AU  - Tomberg K
FAU - Eckstein, Gertrud
AU  - Eckstein G
CN  - KORA
FAU - Kelgo, Piret
AU  - Kelgo P
FAU - Rebane, Tiina
AU  - Rebane T
FAU - Shaw-Hawkins, Sue
AU  - Shaw-Hawkins S
FAU - Howard, Philip
AU  - Howard P
FAU - Onipinla, Abiodun
AU  - Onipinla A
FAU - Dobson, Richard J
AU  - Dobson RJ
FAU - Newhouse, Stephen J
AU  - Newhouse SJ
FAU - Brown, Morris
AU  - Brown M
FAU - Dominiczak, Anna
AU  - Dominiczak A
FAU - Connell, John
AU  - Connell J
FAU - Samani, Nilesh
AU  - Samani N
FAU - Farrall, Martin
AU  - Farrall M
CN  - BRIGHT
FAU - Caulfield, Mark J
AU  - Caulfield MJ
FAU - Munroe, Patricia B
AU  - Munroe PB
FAU - Illig, Thomas
AU  - Illig T
FAU - Wichmann, H-Erich
AU  - Wichmann HE
FAU - Meitinger, Thomas
AU  - Meitinger T
FAU - Laan, Maris
AU  - Laan M
LA  - eng
GR  - G9521010/MRC_/Medical Research Council/United Kingdom
GR  - G0400874/MRC_/Medical Research Council/United Kingdom
GR  - 070191/Z/03/Z/WT_/Wellcome Trust/United Kingdom
GR  - 55005617/HHMI/Howard Hughes Medical Institute/United States
GR  - PG02/128/BHF_/British Heart Foundation/United Kingdom
GR  - G9521010D/MRC_/Medical Research Council/United Kingdom
GR  - 076113/B/04/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090320
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Cadherins)
RN  - 0 (H-cadherin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Blood Pressure
MH  - Cadherins/*genetics
MH  - Cohort Studies
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Hypertension/*genetics/physiopathology
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - White People/*genetics
MH  - Young Adult
PMC - PMC2685752
FIR - Wichmann, H-E
IR  - Wichmann HE
FIR - Peters, A
IR  - Peters A
FIR - Meisinger, C
IR  - Meisinger C
FIR - Illig, T
IR  - Illig T
FIR - Holle, R
IR  - Holle R
FIR - John, J
IR  - John J
FIR - Wallace, Chris
IR  - Wallace C
FIR - Lathrop, Mark
IR  - Lathrop M
FIR - Webster, John
IR  - Webster J
EDAT- 2009/03/24 09:00
MHDA- 2009/07/09 09:00
PMCR- 2009/03/20
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/07/09 09:00 [medline]
PHST- 2009/03/20 00:00 [pmc-release]
AID - ddp135 [pii]
AID - 10.1093/hmg/ddp135 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2009 Jun 15;18(12):2288-96. doi: 10.1093/hmg/ddp135. Epub 2009 Mar 
      20.