PMID- 19304866
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211020
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Print)
IS  - 0269-8811 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - MDMA (ecstasy) use is associated with reduced BOLD signal change during semantic 
      recognition in abstinent human polydrug users: a preliminary fMRI study.
PG  - 187-201
LID - 10.1177/0269881109103203 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA) users have impaired verbal memory, and 
      voxel-based morphometry has shown decreased grey matter in Brodmann area (BA) 18, 
      21 and 45. Because these regions play a role in verbal memory, we hypothesized 
      that MDMA users would show altered brain activation in these areas during 
      performance of a functional magnetic resonance imaging (fMRI) task that probed 
      semantic verbal memory. Polysubstance users enriched for MDMA exposure 
      participated in a semantic memory encoding and recognition fMRI task that 
      activated left BA 9, 18, 21/22 and 45. Primary outcomes were percent blood oxygen 
      level-dependent signal change in left BA 9, 18, 21/22 and 45, accuracy and 
      response time. During semantic recognition, lifetime MDMA use was associated with 
      decreased activation in left BA 9, 18 and 21/22 but not 45. This was partly 
      influenced by contributions from cannabis and cocaine use. MDMA exposure was not 
      associated with accuracy or response time during the semantic recognition task. 
      During semantic recognition, MDMA exposure was associated with reduced regional 
      brain activation in regions mediating verbal memory. These findings partially 
      overlap with previous structural evidence for reduced grey matter in MDMA users 
      and may, in part, explain the consistent verbal memory impairments observed in 
      other studies of MDMA users.
FAU - Raj, V
AU  - Raj V
AD  - Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 
      37072, USA.
FAU - Liang, H C
AU  - Liang HC
FAU - Woodward, N D
AU  - Woodward ND
FAU - Bauernfeind, A L
AU  - Bauernfeind AL
FAU - Lee, J
AU  - Lee J
FAU - Dietrich, M S
AU  - Dietrich MS
FAU - Park, S
AU  - Park S
FAU - Cowan, R L
AU  - Cowan RL
LA  - eng
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - R21 DA020149/DA/NIDA NIH HHS/United States
GR  - DA020149/DA/NIDA NIH HHS/United States
GR  - K12 DA000366/DA/NIDA NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - DA00366/DA/NIDA NIH HHS/United States
GR  - DA015137/DA/NIDA NIH HHS/United States
GR  - R01 DA015137/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090320
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Brain/drug effects/metabolism
MH  - Cocaine-Related Disorders/complications
MH  - Female
MH  - Hallucinogens/*toxicity
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Marijuana Abuse/complications
MH  - Memory/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Oxygen/*blood
MH  - Substance-Related Disorders/complications
MH  - Verbal Learning/drug effects
MH  - Young Adult
PMC - PMC3198867
MID - NIHMS277360
EDAT- 2009/03/24 09:00
MHDA- 2010/04/27 06:00
PMCR- 2011/10/22
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
PHST- 2011/10/22 00:00 [pmc-release]
AID - 0269881109103203 [pii]
AID - 10.1177/0269881109103203 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2010 Feb;24(2):187-201. doi: 10.1177/0269881109103203. Epub 
      2009 Mar 20.