PMID- 19304962
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20220408
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 20
IP  - 4
DP  - 2009 Apr
TI  - Immune reconstitution inflammatory syndrome.
PG  - 221-4
LID - 10.1258/ijsa.2008.008449 [doi]
AB  - Antiretroviral therapy (ART) inhibits HIV replication, allowing recovery of CD4+ 
      T cell numbers and the restoration of immune function; its introduction has led 
      to improved outcomes for individuals with HIV infection. However, it has been 
      observed that some individuals responding to ART experience a clinical 
      deterioration with symptoms and signs of an inflammatory illness. Immune 
      reconstitution inflammatory syndrome (IRIS) results from pathological immune 
      responses occurring during immune reconstitution. IRIS is best considered a group 
      of disorders with a wide range of clinical manifestations, incorporating disease 
      resulting from pathological inflammation to pathogens, immune-mediated 
      inflammatory disease and autoimmune disease. Clinical effects range from a mild, 
      self-limiting illness to severe morbidity and mortality. Clinicians working in 
      the field of HIV medicine can expect to encounter individuals with IRIS. In this 
      review, we discuss definitions, describe clinical presentations, summarize 
      research relating to pathogenesis and identify risk factors, preventive and 
      management strategies.
FAU - Elston, J W T
AU  - Elston JW
AD  - Department of Infection and Tropical Medicine, Castle Hill Hospital, Cottingham, 
      East Yorkshire HU16 5JQ, UK. Hiten.Thaker@hey.nhs.uk
FAU - Thaker, H
AU  - Thaker H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Autoimmune Diseases/diagnosis/immunology
MH  - HIV Infections/*drug therapy/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory 
      Syndrome/*diagnosis/epidemiology/*immunology/prevention & control
MH  - Incidence
MH  - Mycobacterium Infections/complications/immunology
MH  - Mycoses/complications/immunology
MH  - Risk Factors
RF  - 52
EDAT- 2009/03/24 09:00
MHDA- 2009/06/13 09:00
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
AID - 20/4/221 [pii]
AID - 10.1258/ijsa.2008.008449 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2009 Apr;20(4):221-4. doi: 10.1258/ijsa.2008.008449.