PMID- 19304971
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20151119
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 20
IP  - 4
DP  - 2009 Apr
TI  - Identification of oral candidosis, hairy leukoplakia and recurrent oral ulcers as 
      distinct cases of immune reconstitution inflammatory syndrome.
PG  - 259-61
LID - 10.1258/ijsa.2008.008351 [doi]
AB  - Oral lesions such as candidosis, hairy leukoplakia (HL) and oral ulcers are 
      strikingly absent in the numerous reports of immune reconstitution inflammatory 
      syndrome (IRIS). To document oral manifestations attributable to immune 
      reconstitution, we conducted a longitudinal follow-up of a cohort of HIV+ 
      individuals starting highly active antiretroviral therapy (HAART) and completing 
      oral pathology follow-up up to 12 weeks after treatment initiation. HIV-infected 
      patients had oral examinations, CD4+ T-cell count and viral load determinations 
      performed at baseline, and at weeks 4, 8 and 12 after HAART initiation. Among 
      individuals with satisfactory viral response and recovery of > or =50 CD4+ 
      T-cell/microL, eight patients complied with strict IRIS criteria: two developed 
      clinical signs of oral candidosis (OC), two oral ulcers, three HL and one 
      Kaposi's sarcoma. CD4+ T-cell counts at symptom onset suggested no remaining 
      immune suppression. Our findings show that cases of OC, HL and recurrent ulcers 
      can be instances of IRIS.
FAU - Ramirez-Amador, V A
AU  - Ramirez-Amador VA
AD  - Health Care Department, Universidad Autonoma Metropolitana-Xochimilco, Mexico 
      City. rava1863@correo.xoc.uam.mx
FAU - Espinosa, E
AU  - Espinosa E
FAU - Gonzalez-Ramirez, I
AU  - Gonzalez-Ramirez I
FAU - Anaya-Saavedra, G
AU  - Anaya-Saavedra G
FAU - Ormsby, C E
AU  - Ormsby CE
FAU - Reyes-Teran, G
AU  - Reyes-Teran G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Biomarkers)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*diagnosis/etiology
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - Biomarkers/analysis
MH  - Candidiasis, Oral/*diagnosis/etiology
MH  - Cohort Studies
MH  - Diagnosis, Oral
MH  - HIV Infections/drug therapy/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*diagnosis
MH  - Leukoplakia, Hairy/*diagnosis/etiology
MH  - Oral Ulcer/*diagnosis/etiology
MH  - Treatment Failure
EDAT- 2009/03/24 09:00
MHDA- 2009/06/13 09:00
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
AID - 20/4/259 [pii]
AID - 10.1258/ijsa.2008.008351 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2009 Apr;20(4):259-61. doi: 10.1258/ijsa.2008.008351.