PMID- 19304978
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20220321
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 20
IP  - 4
DP  - 2009 Apr
TI  - Abacavir-induced reaction with fever and severe skin rash in a patient tested 
      human leukocyte antigen-B*5701 negative.
PG  - 276-7
LID - 10.1258/ijsa.2008.008318 [doi]
AB  - The most serious adverse event caused by abacavir is the hypersensitivity 
      reaction, which is usually associated with the presence of the human leukocyte 
      antigen (HLA) subtype B*5701, as shown in recent studies. We describe the case of 
      a 41-year-old Caucasian female patient, who tested HLA-B*5701 negative and 
      developed fever and severe skin rash 10 weeks after the start of abacavir 
      therapy. Similar reports suggest that not all severe abacavir-induced adverse 
      events occur as a result of classic hypersensitivity reactions, and can present 
      also in HLA-B*5701-negative patients.
FAU - Calza, L
AU  - Calza L
AD  - Department of Clinical and Experimental Medicine, Section of Infectious Diseases, 
      'Alma Mater Studiorum' University of Bologna, S. Orsola-Malpighi Hospital, 
      Bologna, Italy. leonardo.calza@unibo.it
FAU - Rosseti, N
AU  - Rosseti N
FAU - Biagetti, C
AU  - Biagetti C
FAU - Pocaterra, D
AU  - Pocaterra D
FAU - Colangeli, V
AU  - Colangeli V
FAU - Manfredi, R
AU  - Manfredi R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*57:01 antigen)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Adult
MH  - Dideoxynucleosides/*adverse effects/therapeutic use
MH  - Exanthema/chemically induced/*diagnosis/genetics
MH  - Female
MH  - Fever/chemically induced/*diagnosis/genetics
MH  - HIV Infections/drug therapy
MH  - HIV-1
MH  - HLA-B Antigens/genetics
MH  - Humans
MH  - Reverse Transcriptase Inhibitors/*adverse effects/therapeutic use
EDAT- 2009/03/24 09:00
MHDA- 2009/06/13 09:00
CRDT- 2009/03/24 09:00
PHST- 2009/03/24 09:00 [entrez]
PHST- 2009/03/24 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
AID - 20/4/276 [pii]
AID - 10.1258/ijsa.2008.008318 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2009 Apr;20(4):276-7. doi: 10.1258/ijsa.2008.008318.