PMID- 19306876
OWN - NLM
STAT- MEDLINE
DCOM- 20090504
LR  - 20131121
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 8
DP  - 2009 Apr 17
TI  - The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.
PG  - 1331-6
LID - 10.1016/j.febslet.2009.03.033 [doi]
AB  - Caloric restriction (CR) is known to effectively elongate mammalian life-spans. 
      The compound 2-deoxy-D-glucose (2DG), which is often used as an inhibitor of 
      glucose utilization, is a mimetic agent of CR. In this study, we examined the 
      changes of telomerase and Werner's syndrome RecQ (WRN) helicase after treatment 
      with 2DG, because of the involvement of recQ helicase in the regulation of 
      telomeres. Interestingly, 2DG treatment increased the expression of WRN protein 
      in accordance with induction of its promoter activity and gene expression. 
      Furthermore, the activation of telomerase was observed after 2DG treatment, 
      whereas it resulted in the reduction of cell proliferation. These results suggest 
      that 2DG could up-regulate telomere maintenance factors accompanied with 
      suppression of proliferation.
FAU - Zhou, Bei
AU  - Zhou B
AD  - Department of Gene Regulation, Tokyo University of Science, 2641 Yamazaki, Noda, 
      Chiba 278-8510, Japan.
FAU - Ikejima, Takashi
AU  - Ikejima T
FAU - Watanabe, Takeshi
AU  - Watanabe T
FAU - Iwakoshi, Keiko
AU  - Iwakoshi K
FAU - Idei, Yohei
AU  - Idei Y
FAU - Tanuma, Sei-ichi
AU  - Tanuma S
FAU - Uchiumi, Fumiaki
AU  - Uchiumi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090322
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (DNA Primers)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - EC 2.7.7.49 (Telomerase)
RN  - EC 3.6.4.12 (RecQ Helicases)
SB  - IM
MH  - Base Sequence
MH  - Blotting, Western
MH  - Cell Line, Tumor
MH  - DNA Primers
MH  - Deoxyglucose/*pharmacology
MH  - Enzyme Activation
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Promoter Regions, Genetic
MH  - RecQ Helicases/*genetics
MH  - Telomerase/metabolism
MH  - Werner Syndrome/*enzymology
EDAT- 2009/03/25 09:00
MHDA- 2009/05/05 09:00
CRDT- 2009/03/25 09:00
PHST- 2008/12/17 00:00 [received]
PHST- 2009/03/16 00:00 [revised]
PHST- 2009/03/17 00:00 [accepted]
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/05/05 09:00 [medline]
AID - S0014-5793(09)00223-3 [pii]
AID - 10.1016/j.febslet.2009.03.033 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Apr 17;583(8):1331-6. doi: 10.1016/j.febslet.2009.03.033. Epub 
      2009 Mar 22.