PMID- 19307055
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20101118
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 281
IP  - 2
DP  - 2009 Aug 28
TI  - Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on 
      cell migration, angiogenesis and clinical outcome.
PG  - 151-61
LID - 10.1016/j.canlet.2009.02.025 [doi]
AB  - In this report, we demonstrated that overexpression of tropomyosin-related kinase 
      B (TrkB) was associated with shorter survival in ovarian cancer patients. 
      Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation 
      (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the 
      effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but 
      inhibiting apoptosis, we also report for the first time that exogenous hepatocyte 
      growth factor induced TrkB expression at both mRNA and protein levels as well as 
      phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in 
      ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian 
      cancer.
FAU - Au, Christy W H
AU  - Au CW
AD  - Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong 
      Kong.
FAU - Siu, Michelle K Y
AU  - Siu MK
FAU - Liao, Xiaoyun
AU  - Liao X
FAU - Wong, Esther S Y
AU  - Wong ES
FAU - Ngan, Hextan Y S
AU  - Ngan HY
FAU - Tam, Kar Fai
AU  - Tam KF
FAU - Chan, Dominic C W
AU  - Chan DC
FAU - Chan, Queeny K Y
AU  - Chan QK
FAU - Cheung, Annie N Y
AU  - Cheung AN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cell Line, Tumor
MH  - Cell Movement/*physiology
MH  - Female
MH  - Gene Silencing
MH  - Hepatocyte Growth Factor/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunoprecipitation
MH  - In Situ Nick-End Labeling
MH  - Kaplan-Meier Estimate
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Neovascularization, Pathologic/genetics/*metabolism
MH  - Ovarian Neoplasms/*metabolism/mortality/*pathology
MH  - Prognosis
MH  - RNA, Messenger/analysis
MH  - RNA, Small Interfering
MH  - Receptor, trkB/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Vascular Endothelial Growth Factor Receptor-2/metabolism
MH  - Young Adult
EDAT- 2009/03/25 09:00
MHDA- 2009/07/16 09:00
CRDT- 2009/03/25 09:00
PHST- 2008/08/14 00:00 [received]
PHST- 2009/01/08 00:00 [revised]
PHST- 2009/02/17 00:00 [accepted]
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - S0304-3835(09)00137-2 [pii]
AID - 10.1016/j.canlet.2009.02.025 [doi]
PST - ppublish
SO  - Cancer Lett. 2009 Aug 28;281(2):151-61. doi: 10.1016/j.canlet.2009.02.025.