PMID- 19307792
OWN - NLM
STAT- MEDLINE
DCOM- 20090522
LR  - 20090324
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 87
IP  - 4
DP  - 2009 Feb 27
TI  - No occurrence of de novo HLA antibodies in patients with early corticosteroid 
      withdrawal in a 5-year prospective randomized study.
PG  - 546-8
LID - 10.1097/TP.0b013e3181949d2e [doi]
AB  - The purpose of this study was to determine the effect of early corticosteroid 
      cessation on the occurrence of de novo human leukocyte antigen (HLA) antibody 
      posttransplant. Renal transplant recipients (n=37) were randomized to early 
      corticosteroid withdrawal at day 7 posttransplant (n=21 patients), or to chronic 
      steroids (n=16), all in combination with thymoglobulin as induction agent, 
      tacrolimus and mycophenolic acid as maintenance therapy. To establish the time 
      course of HLA antibody appearance, sera collected pretransplant and for up to 5 
      years posttransplant were screened for the appearance of HLA antibodies. In this 
      5-year longitudinal study, only one patient in the control group developed a de 
      novo donor-specific HLA antibody. We conclude that renal transplant recipients on 
      steroid withdrawal by the end of week 1 are not at higher risk for developing HLA 
      antibodies compared with a standard steroid regimen up to 5 years posttransplant.
FAU - Delgado, Julio C
AU  - Delgado JC
AD  - Department of Pathology, University of Utah, Salt Lake City, UT, USA. 
      julio.delgado@path.utah.edu
FAU - Fuller, Anne
AU  - Fuller A
FAU - Ozawa, Miyuki
AU  - Ozawa M
FAU - Smith, Lonnie
AU  - Smith L
FAU - Terasaki, Paul I
AU  - Terasaki PI
FAU - Shihab, Fuad S
AU  - Shihab FS
FAU - Eckels, David D
AU  - Eckels DD
LA  - eng
SI  - ClinicalTrials.gov/NCT00650468
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adrenal Cortex Hormones/administration & dosage/adverse effects/*therapeutic use
MH  - Adult
MH  - Cadaver
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Isoantibodies/*blood
MH  - Kidney Transplantation/*immunology
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tissue Donors
EDAT- 2009/03/25 09:00
MHDA- 2009/05/23 09:00
CRDT- 2009/03/25 09:00
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/05/23 09:00 [medline]
AID - 00007890-200902270-00013 [pii]
AID - 10.1097/TP.0b013e3181949d2e [doi]
PST - ppublish
SO  - Transplantation. 2009 Feb 27;87(4):546-8. doi: 10.1097/TP.0b013e3181949d2e.