PMID- 19309308
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 47
IP  - 5
DP  - 2009
TI  - Association of interleukin-18 gene promoter polymorphisms with risk of acute 
      myocardial infarction in northern Chinese Han population.
PG  - 523-9
LID - 10.1515/CCLM.2009.130 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) has been suggested to play an important role 
      in coronary arterial disease and its sequelae. The aim of the present study was 
      to investigate the association between IL-18 promoter functional polymorphisms 
      (-607C/A and -137G/C) and acute myocardial infarction (AMI) in northern Chinese 
      Han population. METHODS: We performed a case-control study including 234 patients 
      with AMI and 216 age- and sex-matched controls. Genotyping was performed using 
      sequence specific primer-polymerase chain reaction (PCR-SSP). RESULTS: There were 
      significant differences in the genotype and allele distribution of -607C/A 
      polymorphism of the IL-18 gene between cases and controls. Logistic regression 
      analysis with adjustments for other well-established risk factors revealed that 
      the -607C allele carriers had a significantly increased risk of AMI compared with 
      the non-carriers (OR=1.890, 95% CI 1.196-2.985, p=0.006). No relationship between 
      -137G/C polymorphism and AMI was found. CONCLUSIONS: This study shows for the 
      first time that the IL-18 gene promoter -607C/A polymorphism may be considered a 
      genetic risk factor for AMI in northern Chinese Han population.
FAU - Pei, Fang
AU  - Pei F
AD  - Department of Cardiology, Xinqiao Hospital, Third Military Medical University, 
      Chongqing, People's Republic of China.
FAU - Han, Yaling
AU  - Han Y
FAU - Zhang, Xiaolin
AU  - Zhang X
FAU - Yan, Chenghui
AU  - Yan C
FAU - Huang, Mingfang
AU  - Huang M
FAU - Huang, Lan
AU  - Huang L
FAU - Kang, Jian
AU  - Kang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Testing
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*genetics/immunology
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2009/03/25 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/03/25 09:00
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - 10.1515/CCLM.2009.130 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2009;47(5):523-9. doi: 10.1515/CCLM.2009.130.