PMID- 19309473
OWN - NLM
STAT- MEDLINE
DCOM- 20090811
LR  - 20141120
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 49
IP  - 6
DP  - 2009 Jun
TI  - Transfusion of platelet components prepared with photochemical pathogen 
      inactivation treatment during a Chikungunya virus epidemic in Ile de La Reunion.
PG  - 1083-91
LID - 10.1111/j.1537-2995.2009.02111.x [doi]
AB  - BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Reunion, 
      France, more than 30% of 750,000 inhabitants were infected. Local blood donation 
      was suspended to prevent transfusion-transmitted infection (TT-CHIKV). To sustain 
      the availability of platelet (PLT) components, the Etablissement Francais du Sang 
      implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT 
      components (CPAs). The study assessed the safety of PLT components treated with 
      pathogen inactivation transfused in routine clinical practice. STUDY DESIGN AND 
      METHODS: This was a retrospective observational study using patient medical 
      records and the AFSSAPS hemovigilance database (eFIT) to identify TT-CHIKV and 
      adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT 
      components prepared with pathogen inactivation. RESULTS: During 1 year, 1950 
      INTERCEPT-CPAs were transfused to 335 adult, 51 pediatric, and 41 infant 
      patients. Nineteen AEs were observed in 15 patients and 10 were classified as 
      ATRs. Eight ATRs occurred in 6 pediatric hematology-oncology patients. No ATRs 
      were observed in infants. The most frequently reported signs and symptoms were 
      Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of 
      transfusion-related acute lung injury, TT-sepsis, or TT-CHIKV were detected. 
      CONCLUSIONS: INTERCEPT-CPAs were well tolerated in a broad range of patients, 
      including infants. ATR incidence was low and when present ATRs were of mild 
      severity.
FAU - Rasongles, Patrice
AU  - Rasongles P
AD  - EFS Ile de La Reunion, St Denis, Ile de La Reunion, France.
FAU - Angelini-Tibert, Marie France
AU  - Angelini-Tibert MF
FAU - Simon, Philip
AU  - Simon P
FAU - Currie, Caroline
AU  - Currie C
FAU - Isola, Herve
AU  - Isola H
FAU - Kientz, Daniel
AU  - Kientz D
FAU - Slaedts, Marc
AU  - Slaedts M
FAU - Jacquet, Michele
AU  - Jacquet M
FAU - Sundin, David
AU  - Sundin D
FAU - Lin, Lily
AU  - Lin L
FAU - Corash, Laurence
AU  - Corash L
FAU - Cazenave, Jean Pierre
AU  - Cazenave JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090227
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Furocoumarins)
RN  - K1LDZ0VBC0 (amotosalen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alphavirus Infections/epidemiology/*prevention & control
MH  - Blood Donors
MH  - Chikungunya virus/*drug effects/*radiation effects
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - France/epidemiology
MH  - Furocoumarins/pharmacology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Photochemistry
MH  - Platelet Transfusion/*adverse effects
MH  - Retrospective Studies
MH  - Ultraviolet Rays
EDAT- 2009/03/25 09:00
MHDA- 2009/08/12 09:00
CRDT- 2009/03/25 09:00
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/08/12 09:00 [medline]
AID - TRF02111 [pii]
AID - 10.1111/j.1537-2995.2009.02111.x [doi]
PST - ppublish
SO  - Transfusion. 2009 Jun;49(6):1083-91. doi: 10.1111/j.1537-2995.2009.02111.x. Epub 
      2009 Feb 27.