PMID- 19309534
OWN - NLM
STAT- MEDLINE
DCOM- 20091123
LR  - 20240312
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 12
IP  - 9
DP  - 2009 Oct
TI  - Chronic vagus nerve stimulation induces neuronal plasticity in the rat 
      hippocampus.
PG  - 1209-21
LID - 10.1017/S1461145709000200 [doi]
AB  - Vagus nerve stimulation (VNS) is used to treat pharmacotherapy-resistant epilepsy 
      and depression. However, the mechanisms underlying the therapeutic efficacy of 
      VNS remain unclear. We examined the effects of VNS on hippocampal neuronal 
      plasticity and behaviour in rats. Cell proliferation in the hippocampus of rats 
      subjected to acute (3 h) or chronic (1 month) VNS was examined by injection of 
      bromodeoxyuridine (BrdU) and immunohistochemistry. Expression of doublecortin 
      (DCX) and brain-derived neurotrophic factor (BDNF) was evaluated by 
      immunofluorescence staining. The dendritic morphology of DCX+ neurons was 
      measured by Sholl analysis. Our results show that acute VNS induced an increase 
      in the number of BrdU+ cells in the dentate gyrus that was apparent 24 h and 3 wk 
      after treatment. It also induced long-lasting increases in the amount of DCX 
      immunoreactivity and in the number of DCX+ neurons. Neither the number of BrdU+ 
      cells nor the amount of DCX immunoreactivity was increased 3 wk after the 
      cessation of chronic VNS. Chronic VNS induced long-lasting increases in the 
      amount of BDNF immunoreactivity and the number of BDNF+ cells as well as in the 
      dendritic complexity of DCX+ neurons in the hippocampus. In contrast to chronic 
      imipramine treatment, chronic VNS had no effect on the behaviour of rats in the 
      forced swim or elevated plus-maze tests. Both chronic and acute VNS induced 
      persistent changes in hippocampal neurons that may play a key role in the 
      therapeutic efficacy of VNS. However, these changes were not associated with 
      evident behavioural alterations characteristic of an antidepressant or anxiolytic 
      action.
FAU - Biggio, Francesca
AU  - Biggio F
AD  - Department of Experimental Biology, Centre of Excellence for the Neurobiology of 
      Dependence, University of Cagliari, Cagliari, Italy.
FAU - Gorini, Giorgio
AU  - Gorini G
FAU - Utzeri, Cinzia
AU  - Utzeri C
FAU - Olla, Pierluigi
AU  - Olla P
FAU - Marrosu, Francesco
AU  - Marrosu F
FAU - Mocchetti, Italo
AU  - Mocchetti I
FAU - Follesa, Paolo
AU  - Follesa P
LA  - eng
GR  - R21 NS047977/NS/NINDS NIH HHS/United States
GR  - R21 NS047977-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090324
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - OGG85SX4E4 (Imipramine)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/pharmacology
MH  - Antidepressive Agents, Tricyclic/pharmacology
MH  - *Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation
MH  - Dendrites/physiology
MH  - Dentate Gyrus/physiology
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - *Electric Stimulation Therapy
MH  - Hippocampus/cytology/metabolism/*physiology
MH  - Imipramine/pharmacology
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Models, Animal
MH  - *Motor Activity/drug effects
MH  - *Neuronal Plasticity
MH  - Neurons/metabolism/*physiology
MH  - Neuropeptides/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Vagus Nerve/*physiology
PMC - PMC2879889
MID - NIHMS204606
COIS- Statement of Interest None
EDAT- 2009/03/25 09:00
MHDA- 2009/12/16 06:00
PMCR- 2010/06/02
CRDT- 2009/03/25 09:00
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/06/02 00:00 [pmc-release]
AID - S1461145709000200 [pii]
AID - 10.1017/S1461145709000200 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2009 Oct;12(9):1209-21. doi: 
      10.1017/S1461145709000200. Epub 2009 Mar 24.