PMID- 1931572
OWN - NLM
STAT- MEDLINE
DCOM- 19911217
LR  - 20071114
IS  - 0278-145X (Print)
IS  - 0278-145X (Linking)
VI  - 10
IP  - 3
DP  - 1991 Sep
TI  - Autoimmunity to type VII collagen.
PG  - 232-9
AB  - The epidermolysis bullosa acquisita (EBA) antigen is type VII collagen that is 
      found within the anchoring fibrils of the basement membrane zone beneath 
      stratified epithelia. Autoimmunity to the EBA antigen/type VII collagen has been 
      associated with three diseases: EBA, bullous systemic lupus erythematosus (SLE) 
      and a subset of linear IgA bullous diseases. Although some systemic diseases in 
      which autoimmunity is thought to play a role (eg, inflammatory bowel disease, 
      thyroiditis) have been reported in association with EBA, so far there have not 
      been systemic diseases associated with autoimmunity to type VII collagen other 
      than SLE. In the case of EBA and bullous SLE, it appears that many patients may 
      have a genetic predisposition toward autoimmunity because they share a human 
      leukocyte antigen (HLA) major histocompatibility (MHC) class II cell surface 
      protein, HLA-DR2. The full clinical spectrum of EBA and perhaps other diseases in 
      which there is an association with autoimmunity to type VII collagen is currently 
      being defined.
FAU - Woodley, D T
AU  - Woodley DT
AD  - Department of Dermatology, Stanford University School of Medicine, CA 94305.
FAU - Sarret, Y
AU  - Sarret Y
FAU - Briggaman, R A
AU  - Briggaman RA
LA  - eng
GR  - AR01540/AR/NIAMS NIH HHS/United States
GR  - AR33625/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Semin Dermatol
JT  - Seminars in dermatology
JID - 8211646
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (epidermolysis bullosa acquisita antigen)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Autoantibodies/analysis
MH  - Autoantigens/immunology
MH  - *Autoimmunity
MH  - Basement Membrane/immunology/ultrastructure
MH  - Collagen/*immunology
MH  - Epidermolysis Bullosa Acquisita/immunology
MH  - Humans
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Skin/immunology/ultrastructure
MH  - Skin Diseases, Vesiculobullous/immunology
RF  - 43
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PST - ppublish
SO  - Semin Dermatol. 1991 Sep;10(3):232-9.