PMID- 19317748
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 4
DP  - 2009 Apr
TI  - Characterization of 104 novel alleles at the HLA-A, -B, and -DRB1 loci from 
      National Marrow Donor Program volunteer donors.
PG  - 364-72
LID - 10.1111/j.1399-0039.2009.01226.x [doi]
AB  - One hundred and four novel human leukocyte antigen (HLA) alleles are described 
      from volunteer donors of the National Marrow Donor Program: 37 HLA-A alleles, 37 
      HLA-B alleles, and 30 HLA-DRB1 alleles. Seventeen ( approximately 16%) of the 
      novel alleles were found in multiple individuals and likely are relatively common 
      in the population. Seventy-two ( approximately 69%) of the 104 novel alleles are 
      single nucleotide substitution variants when compared with their most homologous 
      allele. Nine of these single nucleotide variants are silent substitutions and 
      three create null alleles. The remaining novel alleles differ from their most 
      similar allele by two to seven nucleotide substitutions. Some of the novel 
      alleles encode amino acid changes at positions not previously reported to be 
      polymorphic, such as codons 6 and 11 in HLA-A alleles and codons 5, 105, and 141 
      in HLA-B alleles. Interestingly, one of the novel HLA-DRB1 alleles (*1471) has a 
      change that is not the typical glycine/valine dimorphism at codon 86, which plays 
      a key role in peptide binding to DR molecules. This is only the second DRB1 
      allele described that encodes an amino acid other than glycine or valine at this 
      position.
FAU - Lazaro, A M
AU  - Lazaro AM
AD  - Department of Pediatrics, C.W. Bill Young Marrow Donor Research and Recruitment 
      Program, Georgetown University Medical Center, 3970 Reservoir Road NW, 
      Washington, DC 20057, USA.
FAU - Xiao, Y
AU  - Xiao Y
FAU - Regenscheid, A
AU  - Regenscheid A
FAU - Ng, J
AU  - Ng J
FAU - Hurley, C K
AU  - Hurley CK
FAU - Posch, P E
AU  - Posch PE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - Bone Marrow/immunology
MH  - Bone Marrow Transplantation
MH  - HLA Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Tissue Donors
EDAT- 2009/03/26 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/03/26 09:00
PHST- 2009/03/26 09:00 [entrez]
PHST- 2009/03/26 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - TAN1226 [pii]
AID - 10.1111/j.1399-0039.2009.01226.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Apr;73(4):364-72. doi: 10.1111/j.1399-0039.2009.01226.x.