PMID- 19319575
OWN - NLM
STAT- MEDLINE
DCOM- 20100125
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 17
IP  - 12
DP  - 2009 Dec
TI  - Hyperbaric oxygen therapy for late radiation tissue injury in gynaecological 
      patients.
PG  - 1517-21
LID - 10.1007/s00520-009-0619-1 [doi]
AB  - BACKGROUND: Pelvic radiation therapy is an important element of curative therapy 
      for gynaecological cancers. Serious radiation-related complications developing 
      months or years after treatment are known as late radiation tissue injury (LRTI). 
      METHODS: We investigated the possible pain reducing effect of hyperbaric oxygen 
      treatment (HBOT) in a study of 16 patients with LRTI after radiation for 
      gynaecological malignancy. The 16 patients were registered prospectively, 
      underwent HBOT for 21 consecutive days and were followed for a 6-month period 
      after treatment using the Brief Pain Inventory, Montgomery and Aasberg Depression 
      Rating Scale, as well as registration of global patient scores, analgesic 
      consumption and magnetic resonance imaging (MRI) findings. RESULTS: HBOT was 
      shown to have insignificant effect on pain, pain characteristics, daily function, 
      the use of analgesics and MRI-related tissue injury. Fifty percent of the 
      patients still reported some or good effect of the treatment. CONCLUSION: It is 
      not possible to conclude from our study if gynaecological patients with pelvic 
      pain will benefit from HBOT. The application of HBOT to selected patients may be 
      justified, but further research with adequate sample size, as well as the timing 
      of HBOT related to the development of LRTI, is required to establish the optimum 
      patient selection.
FAU - Rud, A Kongsgaard
AU  - Rud AK
AD  - Department of Oncology, Rikshospitalet, The Norwegian Radium Hospital, Oslo, 
      Norway.
FAU - Bjorgo, S
AU  - Bjorgo S
FAU - Kristensen, G B
AU  - Kristensen GB
FAU - Kongsgaard, U E
AU  - Kongsgaard UE
LA  - eng
PT  - Journal Article
DEP - 20090325
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
RN  - 0 (Analgesics)
SB  - IM
MH  - Activities of Daily Living
MH  - Analgesics/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Genital Neoplasms, Female/*radiotherapy
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Magnetic Resonance Imaging/adverse effects/methods
MH  - Middle Aged
MH  - Pelvic Pain/etiology/*therapy
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Radiation Injuries/physiopathology/*therapy
MH  - Time Factors
EDAT- 2009/03/26 09:00
MHDA- 2010/01/26 06:00
CRDT- 2009/03/26 09:00
PHST- 2008/08/06 00:00 [received]
PHST- 2009/03/16 00:00 [accepted]
PHST- 2009/03/26 09:00 [entrez]
PHST- 2009/03/26 09:00 [pubmed]
PHST- 2010/01/26 06:00 [medline]
AID - 10.1007/s00520-009-0619-1 [doi]
PST - ppublish
SO  - Support Care Cancer. 2009 Dec;17(12):1517-21. doi: 10.1007/s00520-009-0619-1. 
      Epub 2009 Mar 25.