PMID- 19320296
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20191009
IS  - 1542-8877 (Print)
IS  - 1542-8877 (Linking)
VI  - 40
IP  - 2
DP  - 2009 Mar-Apr
TI  - Spectral domain optical coherence tomographic imaging of geographic atrophy.
PG  - 96-101
LID - 10.3928/15428877-20090301-16 [doi]
AB  - BACKGROUND AND OBJECTIVE: To compare images of geographic atrophy (GA) obtained 
      using spectral domain optical coherence tomography (SD-OCT) with images obtained 
      using fundus autofluorescence (FAF). PATIENTS AND METHODS: Five eyes from 
      patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of 
      the GA were compared. RESULTS: GA appears bright on SD-OCT compared with the 
      surrounding areas with an intact retinal pigment epithelium because of increased 
      reflectivity from the underlying choroid. SD-OCT and FAF both identified GA 
      reproducibly, and measurement of the area of GA is comparable between the two 
      methods with a mean difference of 2.7% of the total area. CONCLUSION: SD-OCT can 
      identify and quantitate areas of GA. The size and shape of these areas correlate 
      well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging 
      also provides important cross-sectional anatomic information.
FAU - Lujan, Brandon J
AU  - Lujan BJ
AD  - Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 
      Miami, Florida 33136, USA.
FAU - Rosenfeld, Philip J
AU  - Rosenfeld PJ
FAU - Gregori, Giovanni
AU  - Gregori G
FAU - Wang, Fenghua
AU  - Wang F
FAU - Knighton, Robert W
AU  - Knighton RW
FAU - Feuer, William J
AU  - Feuer WJ
FAU - Puliafito, Carmen A
AU  - Puliafito CA
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
GR  - R03 EY016420/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging
JT  - Ophthalmic surgery, lasers & imaging : the official journal of the International 
      Society for Imaging in the Eye
JID - 101155780
SB  - IM
MH  - Aged, 80 and over
MH  - Atrophy
MH  - Female
MH  - Fluorescein Angiography
MH  - Fluorescence
MH  - Fourier Analysis
MH  - Humans
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Retinal Pigment Epithelium/*pathology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2009/03/27 09:00
MHDA- 2009/04/22 09:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
AID - 10.3928/15428877-20090301-16 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging. 2009 Mar-Apr;40(2):96-101. doi: 
      10.3928/15428877-20090301-16.