PMID- 19320568
OWN - NLM
STAT- MEDLINE
DCOM- 20090602
LR  - 20090413
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 25
IP  - 4
DP  - 2009 Apr
TI  - Dendritic cell differentiation and maturation in the presence of HIV type 2 
      envelope.
PG  - 425-31
LID - 10.1089/aid.2008.0247 [doi]
AB  - Dendritic cells (DCs) are fundamental for the initiation of immune responses and 
      are important players in AIDS immunopathogenesis. Impairment of DC function may 
      result from bystander effects of HIV-1 envelope proteins independently of direct 
      HIV-1 infection. HIV-2 envelope proteins are thought to interact with a broader 
      range of receptors than those of HIV-1, and have been shown to have T cell 
      immunosuppressive properties mediated by monocytes. The effects of HIV-2 envelope 
      on DC differentiation and maturation were investigated. The modulatory properties 
      of the HIV-2 envelope on DC generated from monocytes were assessed using both 
      recombinant proteins (HIV-2(ROD) and HIV-2(ALI)) and whole chemically inactivated 
      virus (aldrithiol-2-treated HIV-2(ROD)). DC phenotype was assessed by flow 
      cytometry and DC function by their ability to stimulate allogeneic T cells and to 
      produce cytokines. We demonstrate that HIV-2 Env had no effects upon DC 
      differentiation and maturation despite its broad receptor usage and ability to 
      modulate monocyte function. It is plausible to speculate that a reduced ability 
      of the HIV-2 Env to impair myeloid DC function could represent a contributory 
      factor to the relatively benign course of HIV-2 disease.
FAU - Cavaleiro, Rita
AU  - Cavaleiro R
AD  - Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de 
      Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
FAU - Baptista, Antonio P
AU  - Baptista AP
FAU - Foxall, Russell B
AU  - Foxall RB
FAU - Victorino, Rui M M
AU  - Victorino RM
FAU - Sousa, Ana E
AU  - Sousa AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Recombinant Proteins)
RN  - 0 (env Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - *Cell Differentiation/immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/*cytology/*immunology
MH  - Genes, env/immunology
MH  - HIV-2/*immunology
MH  - Humans
MH  - Monocytes/cytology/immunology
MH  - Recombinant Proteins/genetics/immunology
MH  - env Gene Products, Human Immunodeficiency Virus/genetics/*immunology
EDAT- 2009/03/27 09:00
MHDA- 2009/06/03 09:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/06/03 09:00 [medline]
AID - 10.1089/aid.2008.0247 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2009 Apr;25(4):425-31. doi: 10.1089/aid.2008.0247.