PMID- 19320740
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20090604
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 18
IP  - 6
DP  - 2009 Jun
TI  - In vivo reflectance confocal microscopy of erythematosquamous skin diseases.
PG  - 536-40
LID - 10.1111/j.1600-0625.2008.00822.x [doi]
AB  - BACKGROUND: In vivo reflectance confocal microscopy (RCM) represents a promising 
      imaging tool that allows a non-invasive examination of skin morphology in real 
      time at nearly histological resolution, showing microanatomical structures and 
      individual cells. OBJECTIVES: The aim of our study was to evaluate the diagnostic 
      accuracy of confocal examination of erythematosquamous skin diseases, to define 
      typical RCM-features and assess them for their presence or absence, diagnostic 
      performance and reliability. METHODS: Three independent observers received 
      standardized instructions about diagnostic RCM-features of erythematosquamous 
      skin diseases. A total of 1700 RCM images obtained from 75 patients with 
      psoriasis, contact dermatitis, mycosis fungoides, chronic discoid lupus 
      erythematosus (CDLE) or subacute cutaneous lupus erythematosus (SCLE) and from 10 
      'healthy adults' without any skin disease were evaluated by each observer. 
      RESULTS: Overall, sensitivity and specificity values as observed by three 
      observers were, respectively, 89.13% and 95.41% for psoriasis; 83.33% and 92.31% 
      for contact dermatitis; 62.96% and 94.53% for SCLE/CDLE; and 63.33% and 92.89% 
      for mycosis fungoides. CONCLUSIONS: Reflectance confocal microscopy examination 
      appears to be a promising method for non-invasive assessment of 
      erythematosquamous skin diseases. This study provides a set of well-described 
      morphological criteria with obvious diagnostic impact, which should be used in 
      further investigations.
FAU - Koller, Silvia
AU  - Koller S
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria. 
      silvia.koller@meduni-graz.at
FAU - Gerger, Armin
AU  - Gerger A
FAU - Ahlgrimm-Siess, Verena
AU  - Ahlgrimm-Siess V
FAU - Weger, Wolfgang
AU  - Weger W
FAU - Smolle, Josef
AU  - Smolle J
FAU - Hofmann-Wellenhof, Rainer
AU  - Hofmann-Wellenhof R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090306
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Dermatitis, Contact/pathology
MH  - Erythema/diagnosis/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Lupus Erythematosus, Discoid/pathology
MH  - Microscopy, Confocal/*methods
MH  - Mycosis Fungoides/pathology
MH  - Observer Variation
MH  - Prospective Studies
MH  - Psoriasis/pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Skin Diseases, Papulosquamous/diagnosis/*pathology
MH  - Skin Neoplasms/pathology
EDAT- 2009/03/27 09:00
MHDA- 2009/08/26 09:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
AID - EXD822 [pii]
AID - 10.1111/j.1600-0625.2008.00822.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2009 Jun;18(6):536-40. doi: 10.1111/j.1600-0625.2008.00822.x. Epub 
      2009 Mar 6.