PMID- 19321411
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20181201
IS  - 1607-551X (Print)
IS  - 1607-551X (Linking)
VI  - 25
IP  - 2
DP  - 2009 Feb
TI  - Oxcarbazepine-induced Stevens-Johnson syndrome: a case report.
PG  - 82-6
LID - 10.1016/S1607-551X(09)70045-2 [doi]
AB  - Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome 
      (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to 
      carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, 
      a strong association was found between human leukocyte antigen (HLA) B*1502 and 
      CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, 
      which was induced by oxcarbazepine. HLA genotyping in the patient showed 
      HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of 
      HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further 
      studied.
FAU - Lin, Lung-Chang
AU  - Lin LC
AD  - Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, 
      Taiwan.
FAU - Lai, Ping-Chin
AU  - Lai PC
FAU - Yang, Sheau-Fang
AU  - Yang SF
FAU - Yang, Rei-Cheng
AU  - Yang RC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B15 Antigen)
RN  - 33CM23913M (Carbamazepine)
RN  - VZI5B1W380 (Oxcarbazepine)
SB  - IM
MH  - Anticonvulsants/*adverse effects
MH  - Carbamazepine/adverse effects/*analogs & derivatives
MH  - Child
MH  - Genotype
MH  - HLA-B Antigens/genetics
MH  - HLA-B15 Antigen
MH  - Humans
MH  - Male
MH  - Oxcarbazepine
MH  - Stevens-Johnson Syndrome/*chemically induced/etiology/genetics/pathology
EDAT- 2009/03/27 09:00
MHDA- 2009/07/08 09:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
AID - S1607-551X(09)70045-2 [pii]
AID - 10.1016/S1607-551X(09)70045-2 [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2009 Feb;25(2):82-6. doi: 10.1016/S1607-551X(09)70045-2.