PMID- 19321495
OWN - NLM
STAT- MEDLINE
DCOM- 20090826
LR  - 20231213
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 24
IP  - 7
DP  - 2009 Jul
TI  - Dendritic cell populations in the eutopic and ectopic endometrium of women with 
      endometriosis.
PG  - 1695-703
LID - 10.1093/humrep/dep071 [doi]
AB  - BACKGROUND: Immune alterations may be involved in the pathogenesis and 
      progression of endometriosis. Dendritic cells (DCs) are potent antigen presenting 
      cells that are highly involved in the initiation of the immune response. The aim 
      of this study was to investigate DC populations in the eutopic and ectopic 
      endometrium of women with endometriosis compared with controls. METHODS: 
      Hysterectomy samples were obtained from premenopausal women with (n = 33) and 
      without (n = 28) endometriosis. In addition, paired peritoneal endometriotic 
      lesions and uterine curettings were collected from 32 women with endometriosis. 
      Specimen sections were stained immunohistochemically using antibodies for 
      monoclonal mouse antibodies directed against human CD1a and CD83, which are 
      specific for immature and mature DCs, respectively. RESULTS: The mean density of 
      endometrial CD1a+ DCs in the basal layer was significantly increased in women 
      with endometriosis compared with controls during the proliferative phase only (P 
      = 0.001). There was a highly significant decrease in the density of endometrial 
      CD83+ DCs in women with endometriosis compared with controls in both layers of 
      the endometrium across all phases of the menstrual cycle (P = 0.001). The density 
      of CD1a+ DCs was significantly increased in peritoneal endometriotic lesions (P = 
      0.003) and in the surrounding peritoneum (P = 0.001) compared with paired uterine 
      curettings and peritoneum distant from the lesion. CONCLUSIONS: Both CD1a+ and 
      CD83+ DC populations were altered in the eutopic and ectopic endometrium of women 
      with endometriosis compared with controls. Alterations in these cells, which play 
      a crucial role in the coordination of the immune response, may be involved in 
      pain generation and the pathogenesis of endometriosis.
FAU - Schulke, Lauren
AU  - Schulke L
AD  - Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute 
      for Mothers and Infants, University of Sydney, Sydney 2006, Australia.
FAU - Berbic, Marina
AU  - Berbic M
FAU - Manconi, Frank
AU  - Manconi F
FAU - Tokushige, Natsuko
AU  - Tokushige N
FAU - Markham, Robert
AU  - Markham R
FAU - Fraser, Ian S
AU  - Fraser IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090324
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antigens, CD/biosynthesis
MH  - Antigens, CD1/biosynthesis
MH  - Cell Proliferation
MH  - Dendritic Cells/*cytology/*metabolism
MH  - Endometriosis/*pathology
MH  - Endometrium/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Hysterectomy
MH  - Immunoglobulins/biosynthesis
MH  - Immunohistochemistry/methods
MH  - Membrane Glycoproteins/biosynthesis
MH  - Menstrual Cycle
MH  - Mice
MH  - Middle Aged
MH  - Peritoneum/pathology
MH  - CD83 Antigen
EDAT- 2009/03/27 09:00
MHDA- 2009/08/27 09:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/08/27 09:00 [medline]
AID - dep071 [pii]
AID - 10.1093/humrep/dep071 [doi]
PST - ppublish
SO  - Hum Reprod. 2009 Jul;24(7):1695-703. doi: 10.1093/humrep/dep071. Epub 2009 Mar 
      24.