PMID- 19321768
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 12
DP  - 2009 Mar 25
TI  - A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in 
      extracellular glutamate within the nucleus accumbens.
PG  - 3715-9
LID - 10.1523/JNEUROSCI.5457-08.2009 [doi]
AB  - The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) 
      and projecting to the nucleus accumbens (NAc) core is a critical component of the 
      reward circuitry that underlies reinstatement to cocaine-seeking behavior. 
      Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC-NAc 
      neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking 
      behavior, as well as some cocaine-induced molecular adaptations within the NAc. 
      In the present study, it is demonstrated that a single intra-dmPFC infusion of 
      BDNF prevents cocaine self-administration-induced reduction in basal 
      extracellular glutamate, as well as cocaine prime-induced increases in 
      extracellular glutamate levels within the NAc. These data suggest that intra-PFC 
      BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing 
      cocaine-induced neuroadaptations that alter glutamate neurotransmission within 
      the NAc.
FAU - Berglind, William J
AU  - Berglind WJ
AD  - Department of Neurosciences and Neurobiology of Addiction Research Center, 
      Medical University of South Carolina, Charleston, South Carolina 29425, USA.
FAU - Whitfield, Timothy W Jr
AU  - Whitfield TW Jr
FAU - LaLumiere, Ryan T
AU  - LaLumiere RT
FAU - Kalivas, Peter W
AU  - Kalivas PW
FAU - McGinty, Jacqueline F
AU  - McGinty JF
LA  - eng
GR  - T32 DA007288/DA/NIDA NIH HHS/United States
GR  - F32 DA021460/DA/NIDA NIH HHS/United States
GR  - P50 DA015369-060006/DA/NIDA NIH HHS/United States
GR  - F31 DA018500/DA/NIDA NIH HHS/United States
GR  - F31 DA023743/DA/NIDA NIH HHS/United States
GR  - T32 DA07288/DA/NIDA NIH HHS/United States
GR  - P50 DA015369/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Cocaine/administration & dosage
MH  - Cocaine-Related Disorders/*metabolism
MH  - Conditioning, Operant
MH  - Extinction, Psychological
MH  - Extracellular Space/*metabolism
MH  - Glutamic Acid/*metabolism
MH  - Male
MH  - Nucleus Accumbens/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Synaptic Transmission
PMC - PMC2683065
MID - NIHMS104244
EDAT- 2009/03/27 09:00
MHDA- 2009/04/22 09:00
PMCR- 2009/09/25
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
PHST- 2009/09/25 00:00 [pmc-release]
AID - 29/12/3715 [pii]
AID - 3462635 [pii]
AID - 10.1523/JNEUROSCI.5457-08.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Mar 25;29(12):3715-9. doi: 10.1523/JNEUROSCI.5457-08.2009.