PMID- 19321972
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20151119
IS  - 1423-0348 (Electronic)
IS  - 0033-3190 (Linking)
VI  - 78
IP  - 3
DP  - 2009
TI  - Changes in CREB phosphorylation and BDNF plasma levels during psychotherapy of 
      depression.
PG  - 187-92
LID - 10.1159/000209350 [doi]
AB  - BACKGROUND: The cyclic adenosine monophosphate response element-binding proteins 
      (CREB) and their interaction with brain-derived neurotrophic factor (BDNF) are 
      essential elements in signal transduction pathways important for cellular 
      resilience and neuroplasticity. They play a decisive role in the concept of 
      altered neuroplasticity in major depression. We have previously demonstrated that 
      the increase in phosphorylated CREB (pCREB) in T lymphocytes is significantly 
      associated with clinical improvement in patients treated with antidepressants. In 
      the present study, we focused on patients treated only with psychotherapy to 
      exclude direct pharmacological actions. In addition to pCREB, we also measured 
      the BDNF plasma levels. METHODS: pCREB in T lymphocytes was determined by Western 
      blot; the BDNF plasma levels with solid-phase ELISA. Psychopathology was 
      evaluated with the Hamilton Rating Scale for Depression (HAMD). Thirty patients 
      meeting DSM-IV criteria for major depressive episodes (MDE) were recruited into 
      this 6-week study. They received interpersonal psychotherapy (IPT) twice weekly. 
      RESULTS: After 6 weeks of IPT, 17 patients responded (reduction of > or =50% of 
      baseline HAMD); after 1 week of treatment pCREB increased significantly compared 
      to the nonresponder group. Measurement of the BDNF plasma levels revealed no 
      differences between the responder and nonresponder groups. Furthermore, the 
      correlations between BDNF plasma levels and pCREB were not significant. 
      CONCLUSIONS: The early increase in pCREB is related to treatment response and 
      does not depend on pharmacological interventions or BDNF plasma levels. For the 
      first time, cellular biological markers could be associated with response to 
      psychotherapy.
CI  - Copyright (c) 2009 S. Karger AG, Basel.
FAU - Koch, Jakob M
AU  - Koch JM
AD  - Department of Psychiatry and Psychotherapy, Christian-Albrechts University Kiel, 
      Niemannsweg 147, Kiel, Germany. j.koch@zip-kiel.de
FAU - Hinze-Selch, Dunja
AU  - Hinze-Selch D
FAU - Stingele, Karoline
AU  - Stingele K
FAU - Huchzermeier, Christian
AU  - Huchzermeier C
FAU - Goder, Robert
AU  - Goder R
FAU - Seeck-Hirschner, Mareen
AU  - Seeck-Hirschner M
FAU - Aldenhoff, Josef B
AU  - Aldenhoff JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090324
PL  - Switzerland
TA  - Psychother Psychosom
JT  - Psychotherapy and psychosomatics
JID - 0024046
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
SB  - IM
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - CREB-Binding Protein/*metabolism
MH  - Depressive Disorder, Major/diagnosis/*metabolism/*therapy
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Neuronal Plasticity
MH  - *Phosphorylation
MH  - *Psychotherapy
MH  - Severity of Illness Index
MH  - Signal Transduction
MH  - Surveys and Questionnaires
MH  - T-Lymphocytes/metabolism
EDAT- 2009/03/27 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - 000209350 [pii]
AID - 10.1159/000209350 [doi]
PST - ppublish
SO  - Psychother Psychosom. 2009;78(3):187-92. doi: 10.1159/000209350. Epub 2009 Mar 
      24.