PMID- 19322808
OWN - NLM
STAT- MEDLINE
DCOM- 20091105
LR  - 20211028
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Print)
IS  - 0952-3480 (Linking)
VI  - 22
IP  - 7
DP  - 2009 Aug
TI  - Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex.
PG  - 730-6
LID - 10.1002/nbm.1384 [doi]
AB  - MRI at 7 Tesla has been used to investigate the accumulation of manganese in the 
      occipital cortex of common marmoset monkeys (Callithrix jacchus) after 
      administering four fractionated injections of 30 mg/kg MnCl(2) . 4H(2)O in the 
      tail vein. We found a statistically significant decrease in T(1) in the primary 
      (V1) and secondary (V2) areas of the visual cortex caused by an accumulation of 
      manganese. The larger T(1) shortening in V1 (DeltaT(1) = 640 ms) relative to V2 
      (DeltaT(1) = 490 ms) allowed us to robustly detect the V1/V2 border in vivo using 
      heavily T(1)-weighted MRI. Furthermore, the dorso-medial (DM) and middle-temporal 
      (MT) areas of the visual pathway could be identified by their T(1)-weighted 
      enhancement. We showed by comparison to histological sections stained for 
      cytochrome oxidase (CO) activity that the extent of V1 is accurately identified 
      throughout the visual cortex by manganese-enhanced MRI (MEMRI). This provides a 
      means of visualizing functional cortical regions in vivo and could be used in 
      longitudinal studies of phenomena such as cortical plasticity, and for 
      non-destructive localization of cortical regions to guide in the implementation 
      of functional techniques.
CI  - 2009 John Wiley & Sons, Ltd.
FAU - Bock, Nicholas A
AU  - Bock NA
AD  - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, 
      National Institute of Neurological Disorders and Stroke, National Institutes of 
      Health, Bethesda, MD 20892-1065, USA. bockn@mail.nih.gov
FAU - Kocharyan, Ara
AU  - Kocharyan A
FAU - Silva, Afonso C
AU  - Silva AC
LA  - eng
GR  - Z01 NS003041-01/ImNIH/Intramural NIH HHS/United States
GR  - Z01 NS003041-02/ImNIH/Intramural NIH HHS/United States
GR  - ZIA NS003041-03/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Animals
MH  - Callithrix/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Manganese/*administration & dosage/*pharmacology
MH  - Visual Cortex/*anatomy & histology/*drug effects/metabolism
PMC - PMC3133650
MID - NIHMS240565
EDAT- 2009/03/27 09:00
MHDA- 2009/11/06 06:00
PMCR- 2011/07/12
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2009/11/06 06:00 [medline]
PHST- 2011/07/12 00:00 [pmc-release]
AID - 10.1002/nbm.1384 [doi]
PST - ppublish
SO  - NMR Biomed. 2009 Aug;22(7):730-6. doi: 10.1002/nbm.1384.