PMID- 19323040
OWN - NLM
STAT- MEDLINE
DCOM- 20090626
LR  - 20090327
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 40
IP  - 1
DP  - 2009 Jan
TI  - Characteristics of HIV-infected tuberculosis patients in Thailand.
PG  - 93-103
AB  - To improve understanding about the epidemiology and clinical features of 
      HIV-associated tuberculosis (TB) infection we conducted a prospective, 
      multi-center observational study of HIV-infected TB patients in Thailand. We 
      enrolled HIV-infected patients diagnosed with TB at public health facilities from 
      three provinces and the national infectious diseases referral hospital in 
      Thailand. Patients underwent standardized interviews, evaluations, and laboratory 
      testing at the beginning of TB treatment. We analyzed demographic and clinical 
      characteristics of patients and stratified our findings by level of 
      immune-suppression and whether antiretroviral therapy (ART) was used before TB 
      diagnosis. Of 769 patients analyzed, pulmonary TB was diagnosed in 461 (60%). The 
      median CD4+ T-lymphocyte (CD4) count was 63 cells/microl [interquartile range 
      (IQR), 23-163.5] and the median HIV RNA viral load was 308,000 copies/ml (IQR, 
      51,900-759,000) at the time of TB diagnosis. Methamphetamine use was reported by 
      304 patients (40%), marijuana by 267 patients (35%), and injection drug use by 
      199 patients (26%). Three hundred three patients (40%) reported having been 
      previously incarcerated. Among sexually active patients, 142 (42%) reported never 
      using condoms at all. Patients with CD4 counts <200 cells/microl were 
      significantly more likely than patients with CD4 counts > or =200 cells/microl to 
      have extra-pulmonary TB, fever, fatigue, muscle weakness, no hemoptysis, 
      tachycardia, low body mass index, jaundice, or no pleural effusion. Of the 94 
      patients that received ART before TB diagnosis, the median time from ART 
      initiation to TB diagnosis was 105 days (IQR, 31-468). HIV-infected patients who 
      developed TB after ART initiation were more likely than other HIV-infected TB 
      patients to have extra-pulmonary TB, a normal chest radiograph, low HIV RNA viral 
      load, or a history of previous TB treatment.
FAU - Mankatittham, Wiroj
AU  - Mankatittham W
AD  - Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand.
FAU - Likanonsakul, Sirirat
AU  - Likanonsakul S
FAU - Thawornwan, Unchana
AU  - Thawornwan U
FAU - Kongsanan, Paweena
AU  - Kongsanan P
FAU - Kittikraisak, Wanitchaya
AU  - Kittikraisak W
FAU - Burapat, Channawong
AU  - Burapat C
FAU - Akksilp, Somsak
AU  - Akksilp S
FAU - Sattayawuthipong, Wanchai
AU  - Sattayawuthipong W
FAU - Srinak, Chawin
AU  - Srinak C
FAU - Nateniyom, Sriprapa
AU  - Nateniyom S
FAU - Tasaneeyapan, Theerawit
AU  - Tasaneeyapan T
FAU - Varma, Jay K
AU  - Varma JK
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antitubercular Agents)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/complications/*epidemiology/microbiology
MH  - Adult
MH  - Anti-HIV Agents/adverse effects/therapeutic use
MH  - Antitubercular Agents/adverse effects/therapeutic use
MH  - CD4-Positive T-Lymphocytes
MH  - Female
MH  - HIV Infections/complications/drug therapy/*epidemiology/virology
MH  - HIV-1
MH  - Humans
MH  - Immunocompromised Host
MH  - Male
MH  - Middle Aged
MH  - Observation
MH  - Prospective Studies
MH  - RNA, Viral
MH  - Risk Factors
MH  - Thailand/epidemiology
MH  - Treatment Outcome
MH  - Tuberculosis, Pulmonary/complications/drug therapy/*epidemiology
MH  - Young Adult
EDAT- 2009/03/28 09:00
MHDA- 2009/06/27 09:00
CRDT- 2009/03/28 09:00
PHST- 2009/03/28 09:00 [entrez]
PHST- 2009/03/28 09:00 [pubmed]
PHST- 2009/06/27 09:00 [medline]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2009 Jan;40(1):93-103.