PMID- 19323753
OWN - NLM
STAT- MEDLINE
DCOM- 20090730
LR  - 20090327
IS  - 1750-3841 (Electronic)
IS  - 0022-1147 (Linking)
VI  - 74
IP  - 2
DP  - 2009 Mar
TI  - Evaluation of equol function on anti- or prooxidant status in vivo.
PG  - H65-71
LID - 10.1111/j.1750-3841.2008.01039.x [doi]
AB  - The present study was performed to investigate the effects of equol on oxidative 
      stress and the antioxidant defense system in the livers of mice. Mice were orally 
      administered equol at either 5 or 25 mg/kg body weight/day for 1, 3, or 7 wk. 
      Equol administration significantly inhibited biomarkers of oxidative stress 
      (thiobarbituric acid-reactive substances value, carbonyl content, and serum 
      8-OH-dG) at all doses and for all durations of administration, and this 
      phenomenon was most pronounced at 3 wk. Moreover, catalase and total superoxide 
      dismutase (SOD) activities and their mRNA expression were significantly increased 
      by equol. Although equol increased the glutathione peroxidase (GSH-px) activity 
      in mice treated with equol for 1 wk, long-term administration of equol (7 wk) 
      caused a decrease in the ratio of reduced/oxidized glutathione (GSH/GSSG) and the 
      activities of GSH-px and glutathione reductase (GR). Taken together, these 
      results suggest that equol may act as an antioxidant through an inhibition of 
      oxidative stress and stimulation of catalase and SOD, but can also cause 
      prooxidant effects such as reduction of the GSH/GSSG ratio, depending on the 
      treatment period.
FAU - Choi, E J
AU  - Choi EJ
AD  - Cancer Research Inst, The Catholic Univ of Korea, Seocho-gu, Seoul, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Food Sci
JT  - Journal of food science
JID - 0014052
RN  - 0 (Antioxidants)
RN  - 0 (Oxidants)
RN  - 0 (RNA, Messenger)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Administration, Oral
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Aspartate Aminotransferases/blood
MH  - Catalase/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Oxidants/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/drug effects/genetics
MH  - Superoxide Dismutase/genetics/metabolism
EDAT- 2009/03/28 09:00
MHDA- 2009/07/31 09:00
CRDT- 2009/03/28 09:00
PHST- 2009/03/28 09:00 [entrez]
PHST- 2009/03/28 09:00 [pubmed]
PHST- 2009/07/31 09:00 [medline]
AID - JFDS1039 [pii]
AID - 10.1111/j.1750-3841.2008.01039.x [doi]
PST - ppublish
SO  - J Food Sci. 2009 Mar;74(2):H65-71. doi: 10.1111/j.1750-3841.2008.01039.x.