PMID- 19323922
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20220310
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 122
IP  - 6
DP  - 2009 Mar 20
TI  - Decrease of plasma N-terminal pro beta-type natriuretic peptide as a predictor of 
      clinical improvement after cardiac resynchronization therapy for heart failure.
PG  - 617-21
AB  - BACKGROUND: N-terminal pro beta-type natriuretic peptide (NT pro BNP) has been 
      shown to predict the prognosis and could guide the treatment of heart failure. We 
      aimed to investigate the values of NT pro BNP in predicting the clinical response 
      to cardiac resynchronization therapy (CRT). METHODS: A total of 44 patients with 
      chronic heart failure (34 male and 10 female, mean age of (58 +/- 13) years, New 
      York Heart Association (NYHA) class 3.3 +/- 0.5, QRS duration (150 +/- 14) 
      milliseconds) who underwent successful implantation of a CRT system were enrolled 
      in this study. Pharmacotherapy remained stable during the first 3 months of 
      follow-up. Plasma levels of NT pro BNP were evaluated before and 3 months after 
      implantation. Clinical, echocardiographic and exercise parameters were monitored 
      at each clinical visit after CRT implantation. Receiver operating characteristic 
      analysis and a paired t test were performed to analyze the data. RESULTS: After a 
      mean of (16.3 +/- 5.5) months of follow-up, 11 nonresponders were identified. CRT 
      resulted in a significant reduction in NT pro BNP ((1.70 +/- 1.28) vs (1.07 +/- 
      0.88) pmol/ml, P < 0.001) in responders. Percentage change in NT pro BNP level 
      (DeltaBNP%) was a statistically significant predictor of long term clinical 
      improvement at 3 months of follow-up. CONCLUSIONS: DeltaBNP% from baseline to 3 
      months of follow-up is a predictor of long term response to CRT. NT pro BNP may 
      be a simple method for monitoring the effects of CRT.
FAU - Ding, Li-Gang
AU  - Ding LG
AD  - Centre of Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fu Wai 
      Hospital, Chinese Academy and Medical Sciences & Peking Union Medical College, 
      Beijing 100037, China.
FAU - Hua, Wei
AU  - Hua W
FAU - Zhang, Shu
AU  - Zhang S
FAU - Chu, Jian-Min
AU  - Chu JM
FAU - Chen, Ke-Ping
AU  - Chen KP
FAU - Wang, Yang
AU  - Wang Y
FAU - Wang, Fang-Zheng
AU  - Wang FZ
FAU - Chen, Xin
AU  - Chen X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Chin Med J (Engl). 2009 Mar 20;122(6):608-9. PMID: 19323919
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Failure/*blood/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Time Factors
EDAT- 2009/03/28 09:00
MHDA- 2009/07/08 09:00
CRDT- 2009/03/28 09:00
PHST- 2009/03/28 09:00 [entrez]
PHST- 2009/03/28 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2009 Mar 20;122(6):617-21.