PMID- 19324042
OWN - NLM
STAT- MEDLINE
DCOM- 20090504
LR  - 20131121
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 8
DP  - 2009 Apr 17
TI  - Homocysteine and lipids: S-adenosyl methionine as a key intermediate.
PG  - 1215-25
LID - 10.1016/j.febslet.2009.03.038 [doi]
AB  - An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been 
      suggested. This link is clinically important in management of vascular risk 
      factors especially in elderly people and patients with metabolic syndrome. Higher 
      plasma homocysteine (Hcy) was associated with lower high-density lipoprotein 
      (HDL)-cholesterol level. Moreover, HHCY was associated with disturbed plasma 
      lipids or fatty liver. It seems that hypomethylation associated with HHCY is 
      responsible for lipid accumulation in tissues. Decreased methyl group will 
      decrease the synthesis of phosphatidylcholine, a major phospholipid required for 
      very low-density lipoprotein (VLDL) assembly and homeostasis. The effect of Hcy 
      on HDL-cholesterol is probably related to inhibiting enzymes or molecules 
      participating in HDL-particle assembly.
FAU - Obeid, Rima
AU  - Obeid R
AD  - Department of Clinical Chemistry and Laboratory Medicine, Central Laboratory, 
      University Hospital, Saarland University, D-66424 Homburg/Saar, Germany.
FAU - Herrmann, Wolfgang
AU  - Herrmann W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090325
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Lipids)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7LP2MPO46S (S-Adenosylmethionine)
SB  - IM
EIN - FEBS Lett. 2009 Sep 17;583(18):3107
MH  - Alcoholism/metabolism
MH  - Dyslipidemias/drug therapy/metabolism
MH  - Fatty Liver/metabolism
MH  - Homeostasis
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - Lipids/*blood
MH  - S-Adenosylmethionine/*blood
RF  - 109
EDAT- 2009/03/28 09:00
MHDA- 2009/05/05 09:00
CRDT- 2009/03/28 09:00
PHST- 2008/08/19 00:00 [received]
PHST- 2009/02/20 00:00 [revised]
PHST- 2009/03/02 00:00 [accepted]
PHST- 2009/03/28 09:00 [entrez]
PHST- 2009/03/28 09:00 [pubmed]
PHST- 2009/05/05 09:00 [medline]
AID - S0014-5793(09)00186-0 [pii]
AID - 10.1016/j.febslet.2009.03.038 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Apr 17;583(8):1215-25. doi: 10.1016/j.febslet.2009.03.038. Epub 
      2009 Mar 25.