PMID- 19325239
OWN - NLM
STAT- MEDLINE
DCOM- 20090916
LR  - 20161125
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 28
IP  - 1
DP  - 2009
TI  - Monocyte and neutrophil chemotactic activity at the site of interstitial 
      inflammation in patients on high-flux hemodialysis or hemodiafiltration.
PG  - 47-52
LID - 10.1159/000210037 [doi]
AB  - BACKGROUND/AIMS: We have observed a difference between patients on low-flux 
      hemodialysis (HD) or peritoneal dialysis and patients on hemodiafiltration (HDF) 
      or high-flux HD in the capacity of transmigrated leukocytes to mobilize CD11b in 
      response to inflammatory stimuli compared with healthy subjects. This could be 
      due to different interstitial chemokine concentrations. METHODS: We measured 
      concentrations of circulating and interstitial macrophage inflammatory protein-1 
      alpha (MIP-1 alpha), matrix metalloproteinase-9 (MMP-9)/neutrophil 
      gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 
      (MCP-1) and interleukin-8 (IL-8) in 10 patients on HDF or high-flux HD and 11 
      healthy subjects by using immunoassay. RESULTS: The interstitial concentrations 
      of MIP-1 alpha, MMP-9/NGAL and IL-8 were similar in patients and healthy 
      subjects, while the corresponding concentration of MCP-1 was significantly higher 
      in patients on HDF or high-flux HD as compared with healthy subjects (p < 0.01). 
      CONCLUSION: We suggest that an equal or higher concentration of chemokines in the 
      interstitium in patients with HDF or high-flux HD might be one mechanism 
      responsible for the preserved function of transmigrated leukocytes.
CI  - (c) 2009 S. Karger AG, Basel.
FAU - Olsson, Jenny
AU  - Olsson J
AD  - Department of Nephrology, Malmo University Hospital, Malmo, Sweden. 
      jenny.k.olsson@gmail.com
FAU - Paulsson, Josefin
AU  - Paulsson J
FAU - Dadfar, Elham
AU  - Dadfar E
FAU - Lundahl, Joachim
AU  - Lundahl J
FAU - Moshfegh, Ali
AU  - Moshfegh A
FAU - Jacobson, Stefan H
AU  - Jacobson SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090327
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Interleukin-8)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Acute-Phase Proteins/analysis
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/analysis/blood
MH  - Chemokine CCL3/analysis/blood
MH  - *Chemotaxis
MH  - Extracellular Fluid/chemistry/*immunology
MH  - Female
MH  - *Hemodiafiltration
MH  - Humans
MH  - Interleukin-8/analysis/blood
MH  - Lipocalin-2
MH  - Lipocalins/analysis/blood
MH  - Male
MH  - Matrix Metalloproteinase 9/analysis/blood
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Neutrophils/*immunology
MH  - Proto-Oncogene Proteins/analysis/blood
EDAT- 2009/03/28 09:00
MHDA- 2009/09/17 06:00
CRDT- 2009/03/28 09:00
PHST- 2008/09/01 00:00 [received]
PHST- 2009/01/07 00:00 [accepted]
PHST- 2009/03/28 09:00 [entrez]
PHST- 2009/03/28 09:00 [pubmed]
PHST- 2009/09/17 06:00 [medline]
AID - 000210037 [pii]
AID - 10.1159/000210037 [doi]
PST - ppublish
SO  - Blood Purif. 2009;28(1):47-52. doi: 10.1159/000210037. Epub 2009 Mar 27.