PMID- 1932612
OWN - NLM
STAT- MEDLINE
DCOM- 19911129
LR  - 20191022
IS  - 0142-2782 (Print)
IS  - 0142-2782 (Linking)
VI  - 12
IP  - 7
DP  - 1991 Oct
TI  - Relative bioavailability of oral sustained-release and regular-release oxprenolol 
      tablets at steady-state.
PG  - 493-503
AB  - The relative bioavailability of a test sustained-release (SR) oxprenolol tablet 
      against an approved regular-release (RR) tablet has been investigated at 
      steady-state. In a randomized two-way crossover study, one tablet of 160 mg SR 
      oxprenolol once every 24 h and one tablet of 80 mg RR oxprenolol once every 12 h 
      were given to 12 healthy volunteers for 5 days. Blood samples were collected from 
      each subject just prior to each dose-administration on days 1 through 4, and at 
      scheduled time points on day 5 and analysed for oxprenolol concentration using 
      HPLC. The SR tablet resulted in 42 per cent reduction in mean peak drug levels (p 
      = 0.0341) and a statistically non-significant 14 per cent increase in mean trough 
      levels (p = 0.8357) than the RR tablet. However it required 160 per cent longer 
      time to reach average steady-state concentrations (Css) on day 5 (1.38 h for SR 
      versus 0.53 h for RR; p = 0.0205). The mean area under the plasma drug 
      concentration-time curve at steady state (AUC96-120) with the SR tablet was 
      approximately 18 per cent lower than that observed with the RR tablet, and the 
      degree of fluctuation (DF) was reduced by 30 per cent (2.81 for SR versus 4.11 
      for RR; p = 0.0069). On average, a single dose of SR tablet and two doses of RR 
      tablets maintained the drug levels above a constant Css of 204.6 ng ml-1 for 7.88 
      and 7.65 h, respectively (p = 0.3513).
FAU - Gupta, P K
AU  - Gupta PK
AD  - Department of Pharmacy, University of Otago, Dunedin, New Zealand.
FAU - Lim, J K
AU  - Lim JK
FAU - Zoest, A R
AU  - Zoest AR
FAU - Lam, F C
AU  - Lam FC
FAU - Hung, C T
AU  - Hung CT
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Biopharm Drug Dispos
JT  - Biopharmaceutics & drug disposition
JID - 7911226
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Tablets)
RN  - 519MXN9YZR (Oxprenolol)
SB  - IM
MH  - Adult
MH  - Biological Availability
MH  - Chromatography, High Pressure Liquid
MH  - Delayed-Action Preparations
MH  - Humans
MH  - Male
MH  - Oxprenolol/*administration & dosage/blood/pharmacokinetics
MH  - Tablets
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1002/bdd.2510120703 [doi]
PST - ppublish
SO  - Biopharm Drug Dispos. 1991 Oct;12(7):493-503. doi: 10.1002/bdd.2510120703.