PMID- 19328225
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20171116
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 44
IP  - 6-7
DP  - 2009 Jun-Jul
TI  - Metabolic rate depression is induced by caloric restriction and correlates with 
      rate of development and lifespan in a parthenogenetic insect.
PG  - 413-9
LID - 10.1016/j.exger.2009.03.004 [doi]
AB  - Caloric restriction (CR) extends lifespan in most animals, but the mechanisms 
      underlying this phenomenon are the subject of much debate. We investigated the 
      association between longevity and resting metabolic rate (RMR) in Indian stick 
      insects (Carausius morosus) by (i) determining the appropriate scaling 
      coefficient for calculating mass-corrected RMR of insects throughout development, 
      (ii) quantifying the response of RMR to diet history, and (iii) correlating RMR 
      in multiple life-history stages with adult and total lifespan. Over a range of 
      body sizes, whole-body RMR (measured as oxygen consumption rate) scaled linearly 
      with body mass. Mass-specific RMR decreased in response to CR, particularly when 
      food was restricted during juvenile stages. With one exception, RMR of insects in 
      different life-history stages matched current feeding level and was not 
      substantially affected by intake history. Total lifespan was affected by intake, 
      with insects that experienced CR early in development living longer than insects 
      that were fed ad libitum. Although CR was associated with extended total lifespan 
      and decreased RMR, it was also associated with shortened adult lifespan. Thus, we 
      found limited evidence that decreased RMR plays a causative role in determining 
      longevity. Instead, CR and decreased RMR were associated with slower progression 
      through pre-reproductive life-history stages.
FAU - Roark, Alison M
AU  - Roark AM
AD  - Department of Zoology, University of Florida, Box 118525, Gainesville, FL 
      32611-8525, USA. roark@hood.edu
FAU - Bjorndal, Karen A
AU  - Bjorndal KA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090326
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Animals
MH  - Body Size
MH  - Caloric Restriction
MH  - Energy Metabolism/*physiology
MH  - Humans
MH  - Insecta
MH  - Longevity/*physiology
MH  - Oxygen Consumption/*physiology
MH  - Species Specificity
EDAT- 2009/03/31 09:00
MHDA- 2010/11/06 06:00
CRDT- 2009/03/31 09:00
PHST- 2009/01/08 00:00 [received]
PHST- 2009/03/10 00:00 [revised]
PHST- 2009/03/17 00:00 [accepted]
PHST- 2009/03/31 09:00 [entrez]
PHST- 2009/03/31 09:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - S0531-5565(09)00059-X [pii]
AID - 10.1016/j.exger.2009.03.004 [doi]
PST - ppublish
SO  - Exp Gerontol. 2009 Jun-Jul;44(6-7):413-9. doi: 10.1016/j.exger.2009.03.004. Epub 
      2009 Mar 26.