PMID- 19328920 OWN - NLM STAT- MEDLINE DCOM- 20090729 LR - 20211203 IS - 0041-1345 (Print) IS - 1873-2623 (Electronic) IS - 0041-1345 (Linking) VI - 41 IP - 2 DP - 2009 Mar TI - Dendritic cell therapy in composite tissue allotransplantation. PG - 537-8 LID - 10.1016/j.transproceed.2009.01.011 [doi] AB - Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy. FAU - Thomson, A W AU - Thomson AW AD - Departments of Surgery and Immunology, Starzl Transplantation Institute and Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. thomsonaw@upmc.edu FAU - Sacks, J M AU - Sacks JM FAU - Kuo, Y-R AU - Kuo YR FAU - Ikeguchi, R AU - Ikeguchi R FAU - Horibe, E K AU - Horibe EK FAU - Unadkat, J AU - Unadkat J FAU - Solari, M G AU - Solari MG FAU - Feili-Hariri, M AU - Feili-Hariri M FAU - Lee, W P A AU - Lee WP LA - eng GR - R01 AI060994/AI/NIAID NIH HHS/United States GR - R01 AI060994-04/AI/NIAID NIH HHS/United States GR - R01 AI067541/AI/NIAID NIH HHS/United States GR - R01 AI067541-02/AI/NIAID NIH HHS/United States PT - Journal Article PL - United States TA - Transplant Proc JT - Transplantation proceedings JID - 0243532 RN - 0 (Immunosuppressive Agents) SB - IM MH - Bone Marrow Cells/immunology MH - Dendritic Cells/*immunology/transplantation MH - Graft Survival/*physiology MH - Humans MH - Immune Tolerance MH - Immunosuppression Therapy/methods MH - Immunosuppressive Agents/therapeutic use MH - Spleen/immunology MH - T-Lymphocytes/immunology MH - Tissue Transplantation/*pathology MH - Transplantation, Homologous/*immunology/pathology PMC - PMC2784640 MID - NIHMS137469 EDAT- 2009/03/31 09:00 MHDA- 2009/07/30 09:00 PMCR- 2010/03/01 CRDT- 2009/03/31 09:00 PHST- 2009/03/31 09:00 [entrez] PHST- 2009/03/31 09:00 [pubmed] PHST- 2009/07/30 09:00 [medline] PHST- 2010/03/01 00:00 [pmc-release] AID - S0041-1345(09)00012-8 [pii] AID - 10.1016/j.transproceed.2009.01.011 [doi] PST - ppublish SO - Transplant Proc. 2009 Mar;41(2):537-8. doi: 10.1016/j.transproceed.2009.01.011.