PMID- 19328949
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20090330
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 41
IP  - 2
DP  - 2009 Mar
TI  - Mannose binding lectin (+54) exon 1 gene polymorphism in Tunisian kidney 
      transplant patients.
PG  - 660-2
LID - 10.1016/j.transproceed.2009.01.030 [doi]
AB  - Mannose-binding lectin (MBL), a collagen-like serum protein, is a key component 
      of innate immunity. MBL binding to carbohydrates present on pathogens mediates 
      lectin-dependent activation of the complement pathway. There is growing interest 
      in the importance of innate immunity in host defense, particularly when adaptive 
      immunity is compromised. Three single nucleotide polymorphisms (SNPs) of the MBL 
      gene have been described in the first exon to be associated with low MBL serum 
      concentrations as well as impaired MBL structure and function. Clinical studies 
      have shown that these MBL SNPs are associated with increased susceptibility to 
      infections, especially in immunocompromised patients. To investigate the 
      association between acute kidney transplant rejection and polymorphism at codon 
      54 of the MBL gene, the DNA genomic of 133 renal transplant recipients and 117 
      healthy blood donors was analyzed by restriction fragment length 
      polymorphism-polymerase chain reaction. The patients were classified into two 
      groups: group 1 included 32 HLA-identical recipients and group 2, 101 one 
      haplo-identical recipients. Forty-eight (36.1%) subjects had developed one or 
      more acute rejection episodes (AREs) within the first 6 months after 
      transplantation: 9 in group 1 (28.12%) and 39 in group 2 (38.61%). The genotype 
      and allele frequencies of (+54) MBL gene polymorphism among patients and controls 
      did not reveal a significant difference. However, the frequency of MBL-B mutant 
      allele was increased among patients with AREs compared with those without AREs: 
      group 1 (0.167 vs 0.065) versus group 2 (0.205 vs 0.105). Although the difference 
      was not significant, perhaps because of the small number of patients, the MBL at 
      codon (+54) polymorphism could be involved in the susceptibility of Tunisian 
      kidney transplant recipients to acute allograft rejection episodes.
FAU - Gorgi, Y
AU  - Gorgi Y
AD  - Immunology Laboratory, Charles Nicolle Hospital, Tunis, Tunisia. 
      yousr_gorgi@yahoo.fr
FAU - Sfar, I
AU  - Sfar I
FAU - Aouadi, H
AU  - Aouadi H
FAU - Makhlouf, M
AU  - Makhlouf M
FAU - Abderrahim, E
AU  - Abderrahim E
FAU - Jendoubiayed, S
AU  - Jendoubiayed S
FAU - Bardi, R
AU  - Bardi R
FAU - Ben Abdallah, T
AU  - Ben Abdallah T
FAU - Ayed, K
AU  - Ayed K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Codon)
RN  - 0 (HLA Antigens)
RN  - 0 (Mannose-Binding Lectin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Blood Donors
MH  - Codon/genetics
MH  - DNA/blood/genetics/isolation & purification
MH  - Exons/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft Rejection/genetics/immunology
MH  - HLA Antigens/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/immunology/*physiology
MH  - Male
MH  - Mannose-Binding Lectin/*genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Tunisia
MH  - Young Adult
EDAT- 2009/03/31 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/03/31 09:00
PHST- 2009/03/31 09:00 [entrez]
PHST- 2009/03/31 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S0041-1345(09)00032-3 [pii]
AID - 10.1016/j.transproceed.2009.01.030 [doi]
PST - ppublish
SO  - Transplant Proc. 2009 Mar;41(2):660-2. doi: 10.1016/j.transproceed.2009.01.030.