PMID- 19329405 OWN - NLM STAT- MEDLINE DCOM- 20090710 LR - 20131121 IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 18 IP - 1 DP - 2009 TI - Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk. PG - 121-30 AB - OBJECTIVE: To investigate the effect of supplementation with multivitamin and mineral on blood pressure and C-reactive protein (CRP) in obese women with increased cardiovascular disease risk as having hypertension, hyperglycemia or hyperlipemia. SUBJECTS AND METHODS: 128 obese Chinese women aged 18-55 years with increased cardiovascular disease risk participated in a 26-week randomized, double-blind, placebo-controlled trial. Subjects were randomized to four groups, and received either one tablet of high-dose multivitamin and mineral supplement (MMS), or one tablet of low-dose MMS (Low MMS), or calcium 162 mg (Calcium) or identical placebo (Placebo) daily during the study. Diastolic blood pressure (DBP), systolic blood pressure (SBP) and serum concentrations of CRP were measured at baseline and end-trial. RESULTS: At baseline, the subjects had an average age of 42.0+/-7.1 years and BMI of 30.9+/-2.8 kg/m2. There were no significant differences between the four groups in baseline characteristics. One hundred and seventeen subjects completed the study. After 26-week supplementation, both SBP and DBP were significantly lower in the MMS group compared to the placebo group (p < 0.05). There was also a non-significant trend of lower DBP at 26-week in the MMS and calcium groups compared to baseline (p < 0.08). At 26-week, the MMS group also had significantly lower serum concentrations of CRP compared with that of baseline and the placebo group (p < 0.05). CONCLUSIONS: Our results showed that supplementation with adequate multivitamin and mineral supplement could reduce blood pressure and serum CRP in obese women with increased cardiovascular disease risk. FAU - Wang, Cheng AU - Wang C AD - Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. China. FAU - Li, Ying AU - Li Y FAU - Zhu, Kun AU - Zhu K FAU - Dong, Yan-Mei AU - Dong YM FAU - Sun, Chang-Hao AU - Sun CH LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 0 (Minerals) RN - 0 (Vitamins) RN - 9007-41-4 (C-Reactive Protein) RN - E1UOL152H7 (Iron) RN - J41CSQ7QDS (Zinc) RN - SY7Q814VUP (Calcium) RN - TLM2976OFR (Riboflavin) RN - X66NSO3N35 (Thiamine) SB - IM MH - Adolescent MH - Blood Pressure/*drug effects MH - C-Reactive Protein/*metabolism MH - Calcium/blood/*therapeutic use MH - China MH - *Dietary Supplements MH - Double-Blind Method MH - Female MH - Humans MH - Hyperglycemia/complications/drug therapy MH - Hyperlipidemias/complications/drug therapy MH - Hypertension/complications/drug therapy MH - Iron/blood MH - Middle Aged MH - Minerals/*therapeutic use MH - Obesity/complications/*drug therapy MH - Riboflavin/blood MH - Thiamine/blood MH - Vitamins/*therapeutic use MH - Zinc/blood EDAT- 2009/03/31 09:00 MHDA- 2009/07/11 09:00 CRDT- 2009/03/31 09:00 PHST- 2009/03/31 09:00 [entrez] PHST- 2009/03/31 09:00 [pubmed] PHST- 2009/07/11 09:00 [medline] PST - ppublish SO - Asia Pac J Clin Nutr. 2009;18(1):121-30.