PMID- 19330778
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20220408
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 153B
IP  - 1
DP  - 2010 Jan 5
TI  - Positive association between the brain-derived neurotrophic factor (BDNF) gene 
      and bipolar disorder in the Han Chinese population.
PG  - 275-9
LID - 10.1002/ajmg.b.30953 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is the most widely distributed 
      neurotrophin in the central nervous system (CNS), and services many biological 
      functions such as neural survival, differentiation, and plasticity. Previous 
      studies have suggested that the Val66Met (also known as rs6265 or G196A) variant 
      of BDNF is associated with bipolar disorder (BPD), but the results have been 
      inconclusive. We therefore genotyped the Val66Met polymorphism in a Han Chinese 
      population sample (498 cases and 501 control subjects). We found that the BDNF 
      genotype is associated with BPD in this population (chi(2) = 9.4666, df = 2, P = 
      0.00884). Furthermore, our data suggested that the Met allele rather than the Val 
      allele increased the risk for BPD in our Han population (OR = 1.44; 95% CI = 
      1.070-1.950; P = 0.016). Further studies are necessary to elucidate the 
      involvement of the BDNF gene in the pathophysiology of BPD.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Xu, Jie
AU  - Xu J
AD  - Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences, Shanghai, PR China.
FAU - Liu, Yun
AU  - Liu Y
FAU - Wang, Peng
AU  - Wang P
FAU - Li, Sheng
AU  - Li S
FAU - Wang, Yabing
AU  - Wang Y
FAU - Li, Jun
AU  - Li J
FAU - Zhou, Daizhan
AU  - Zhou D
FAU - Chen, Zhuo
AU  - Chen Z
FAU - Zhao, Teng
AU  - Zhao T
FAU - Wang, Ting
AU  - Wang T
FAU - Xu, He
AU  - Xu H
FAU - Yang, Yifeng
AU  - Yang Y
FAU - Feng, Guoyin
AU  - Feng G
FAU - He, Lin
AU  - He L
FAU - Yu, Lan
AU  - Yu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - China
MH  - *Ethnicity
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Valine/genetics
EDAT- 2009/03/31 09:00
MHDA- 2010/03/24 06:00
CRDT- 2009/03/31 09:00
PHST- 2009/03/31 09:00 [entrez]
PHST- 2009/03/31 09:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - 10.1002/ajmg.b.30953 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):275-9. doi: 
      10.1002/ajmg.b.30953.