PMID- 19331129
OWN - NLM
STAT- MEDLINE
DCOM- 20090416
LR  - 20211122
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 29
IP  - 1
DP  - 2009 Jan
TI  - Gene amplification of Myc and its coamplification with ERBB2 and EGFR in 
      gallbladder adenocarcinoma.
PG  - 19-26
AB  - BACKGROUND: Among the combinations of coamplified genes, Myc and ERBB2 or EGFR 
      have attracted much attention for their relevance to cytogenetics, carcinogenesis 
      and cancer therapy. MATERIALS AND METHODS: Gene amplification of Myc, ERBB2 and 
      EGFR were examined on 97 formalin-fixed and paraffin-embedded gallbladder 
      carcinomas, by fluorescence in situ hybridization (FISH). RESULTS: FISH revealed 
      three tumors had Myc amplification. By dual color FISH, one of these three tumors 
      had two populations of tumor cells with the coexistence of amplified Myc and 
      ERBB2, and Myc and EGFR. The second tumor had a high level of amplification of 
      Myc without amplification of ERBB2 or EGFR. The third tumor had a low level of 
      coamplification of Myc and ERBB2. A case of polysomy 8 also demonstrated 
      amplification of ERBB2 and EGFR. CONCLUSION: The present study shows that genomic 
      instability due to Myc amplification may cause specific amplification of EGFR 
      and/or ERBB2.
FAU - Ooi, Akishi
AU  - Ooi A
AD  - Department of Molecular and Cellular Pathology, Kanazawa University Graduate 
      School of Medical Science, Ishikawa. aooi@med.kanazawa-u.ac.jp
FAU - Suzuki, Shioto
AU  - Suzuki S
FAU - Nakazawa, Kumiko
AU  - Nakazawa K
FAU - Itakura, Jun
AU  - Itakura J
FAU - Imoto, Issei
AU  - Imoto I
FAU - Nakamura, Hiroyuki
AU  - Nakamura H
FAU - Dobashi, Yoh
AU  - Dobashi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adenocarcinoma/enzymology/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - ErbB Receptors/biosynthesis/*genetics
MH  - Female
MH  - Gallbladder Neoplasms/enzymology/*genetics/pathology
MH  - Gene Amplification
MH  - *Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Receptor, ErbB-2/biosynthesis/*genetics
EDAT- 2009/04/01 09:00
MHDA- 2009/04/17 09:00
CRDT- 2009/04/01 09:00
PHST- 2009/04/01 09:00 [entrez]
PHST- 2009/04/01 09:00 [pubmed]
PHST- 2009/04/17 09:00 [medline]
PST - ppublish
SO  - Anticancer Res. 2009 Jan;29(1):19-26.