PMID- 19331133
OWN - NLM
STAT- MEDLINE
DCOM- 20090416
LR  - 20090331
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 29
IP  - 1
DP  - 2009 Jan
TI  - Adhesion/growth-regulatory tissue lectin galectin-1 in relation to 
      angiogenesis/lymphocyte infiltration and prognostic relevance of stromal 
      up-regulation in laryngeal carcinomas.
PG  - 59-65
AB  - BACKGROUND: Galectin-1 has been found to modulate lymphocyte invasion in 
      inflammation and to be involved in angiogenesis in models, thus prompting 
      examination of its clinical relevance in laryngeal cancer. PATIENTS AND METHODS: 
      Immunohistochemical processing of tissue sections (n=53) from patients with stage 
      I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a 
      specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was 
      combined with quantitative morphometric analysis. RESULTS: Lectin presence in the 
      tumor and endothelial cells was positively correlated, while a negative 
      relationship to the number of CD45-positive lymphocytes was demonstrated. No 
      association was seen with the extent of neovascularization. The mean optical 
      density (MOD) of lectin-dependent staining in the tumor stroma was significantly 
      increased compared to normal stroma. CONCLUSION: Galectin-1 was not associated 
      with angiogenesis in the studied cohort while galectin-1 in endothelial cells may 
      negatively influence lymphocyte invasion and the mean optical density for the 
      stromal galectin-1 signal is up-regulated in tumors.
FAU - Saussez, Sven
AU  - Saussez S
AD  - Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of 
      Mons-Hainaut, Mons, Belgium. sven.saussez@umh.ac.be
FAU - Decaestecker, Christine
AU  - Decaestecker C
FAU - Cludts, Stephanie
AU  - Cludts S
FAU - Ernoux, Perle
AU  - Ernoux P
FAU - Chevalier, Dominique
AU  - Chevalier D
FAU - Smetana, Karel Jr
AU  - Smetana K Jr
FAU - Andre, Sabine
AU  - Andre S
FAU - Leroy, Xavier
AU  - Leroy X
FAU - Gabius, Hans-Joachim
AU  - Gabius HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Galectin 1)
RN  - 0 (LGALS1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*blood supply/*immunology/pathology
MH  - Female
MH  - Galectin 1/biosynthesis/genetics/immunology/*physiology
MH  - Humans
MH  - Laryngeal Neoplasms/*blood supply/*immunology/pathology
MH  - Lymphocyte Activation
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/metabolism/pathology
MH  - Prognosis
MH  - Stromal Cells/immunology/metabolism/pathology
MH  - Up-Regulation
EDAT- 2009/04/01 09:00
MHDA- 2009/04/17 09:00
CRDT- 2009/04/01 09:00
PHST- 2009/04/01 09:00 [entrez]
PHST- 2009/04/01 09:00 [pubmed]
PHST- 2009/04/17 09:00 [medline]
PST - ppublish
SO  - Anticancer Res. 2009 Jan;29(1):59-65.