PMID- 19331200
OWN - NLM
STAT- MEDLINE
DCOM- 20090407
LR  - 20090331
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 29
IP  - 2
DP  - 2009 Feb
TI  - Concomitant overexpression of heat-shock protein 70 and HLA class-I in hepatitis 
      C virus-related hepatocellular carcinoma.
PG  - 539-44
AB  - BACKGROUND: Human leukocyte antigen (HLA) class I expression is reportedly 
      frequently reduced in cancer. We examined heat-shock protein (HSP) expression in 
      hepatocellular carcinoma (HCC). PATIENTS AND METHODS: HCV-related HCC was 
      examined in 73 patients who had undergone hepatectomy, and the relationship 
      between HSP70 and HLA class I expressions, clinicopathological factors and 
      survival was evaluated. RESULTS: Immunohistochemically positive results for HSP70 
      and HLA class I were seen in 67 (92%) and 43 cases (59%), respectively, while 38 
      patients (52%) were positive for both. Increased HSP70 immunoreactivity was 
      significantly associated with high histological grade of tumor differentiation (p 
      = 0.0179), whereas reduced HLA class I immunoreactivity was significantly 
      associated with large tumor size (p = 0.0082). No differences were apparent 
      between disease-free and overall survival in regard to expression levels. 
      CONCLUSION: These results suggest that HSP70 expression may be related to tumor 
      differentiation and HLA class I loss may occur with tumor growth in HCV-related 
      HCC.
FAU - Yoshida, Shin
AU  - Yoshida S
AD  - Department of Digestive Surgery and Surgical Oncology (Department of Surgery II), 
      Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.
FAU - Hazama, Shoichi
AU  - Hazama S
FAU - Tokuno, Kazuhisa
AU  - Tokuno K
FAU - Sakamoto, Kazuhiko
AU  - Sakamoto K
FAU - Takashima, Motonari
AU  - Takashima M
FAU - Tamesa, Takao
AU  - Tamesa T
FAU - Torigoe, Toshihiko
AU  - Torigoe T
FAU - Sato, Noriyuki
AU  - Sato N
FAU - Oka, Masaaki
AU  - Oka M
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (HLA Antigens)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/immunology/*metabolism/pathology/virology
MH  - Female
MH  - HLA Antigens/*biosynthesis
MH  - HSP70 Heat-Shock Proteins/*biosynthesis
MH  - Hepacivirus/*isolation & purification
MH  - Hepatitis C/immunology/*metabolism/pathology
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/immunology/*metabolism/pathology/virology
MH  - Male
MH  - Middle Aged
EDAT- 2009/04/01 09:00
MHDA- 2009/04/08 09:00
CRDT- 2009/04/01 09:00
PHST- 2009/04/01 09:00 [entrez]
PHST- 2009/04/01 09:00 [pubmed]
PHST- 2009/04/08 09:00 [medline]
PST - ppublish
SO  - Anticancer Res. 2009 Feb;29(2):539-44.