PMID- 19331717
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 30
IP  - 1
DP  - 2009 Jan-Feb
TI  - Elevated serum immunoglobulin E (IgE): when to suspect hyper-IgE syndrome-A 
      10-year pediatric tertiary care center experience.
PG  - 23-7
LID - 10.2500/aap.2009.30.3193 [doi]
AB  - Elevated serum immunoglobulin E(IgE) can be caused by allergies, infections and 
      immune conditions including hyper IgE syndrome (HIES). HIES is a rare primary 
      immunodeficiency disease most commonly characterized by a triad of findings, 
      including increased serum IgE levels, recurrent skin abscesses, and pneumonias 
      leading to pneumatocele formation. The objective of this study was to 
      characterize the clinical profile of patients presenting with increased IgE 
      levels (>or=2000 IU/mL) focusing specifically on HIES. A database search 
      identified 70 patients in the pediatric age range (<or=18 yrs.) between January 
      1997 and December 2006 who had an IgE level of >or=2000 IU/mL. Charts were 
      abstracted for clinical diagnosis, comorbidities, and laboratory parameters. Data 
      were analyzed using the students t-test, Wilcoxon signed rank test, and 
      univariate/multivariate regression models. Clinical diagnosis in 70 patients with 
      elevated IgE levels were: atopic diseases (n = 54; 77%), parasitic diseases (n = 
      1; 1.5%), malignancy (n = 2; 3%), and HIES (n = 6; 8%), among other causes. There 
      was a statistically significant association between IgE levels and the severity 
      of eczema (p = 0.009). Ninety percent of the subjects with IgE level >or=2000 
      IU/mL did not have HIES. There was no correlation between IgE levels and the 
      diagnosis of HIES (p = 0.5). A variety of clinical situations result in an 
      elevated IgE level, with atopy being the most common cause. In the absence of 
      typical clinical features, elevated serum IgE levels are not predictive of HIES.
FAU - Joshi, Avni Y
AU  - Joshi AY
AD  - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, 
      Minnesota, USA. joshi.avni@mayo.edu
FAU - Iyer, Vivek N
AU  - Iyer VN
FAU - Boyce, Thomas G
AU  - Boyce TG
FAU - Hagan, John B
AU  - Hagan JB
FAU - Park, Miguel A
AU  - Park MA
FAU - Abraham, Roshini S
AU  - Abraham RS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Databases, Genetic
MH  - Eczema/blood/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/*genetics/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Job Syndrome/blood/*diagnosis/*immunology/physiopathology
MH  - Male
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Statistics as Topic
EDAT- 2009/04/01 09:00
MHDA- 2009/05/15 09:00
CRDT- 2009/04/01 09:00
PHST- 2009/04/01 09:00 [entrez]
PHST- 2009/04/01 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
AID - 10.2500/aap.2009.30.3193 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2009 Jan-Feb;30(1):23-7. doi: 10.2500/aap.2009.30.3193.