PMID- 19332097
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20221207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 33
IP  - 4
DP  - 2009 Jun 15
TI  - Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or 
      SNRI-refractory depression.
PG  - 722-6
LID - 10.1016/j.pnpbp.2009.03.020 [doi]
AB  - In the present study, we compared plasma levels of interleukin-6 (IL-6), tumor 
      necrosis factor-alpha(TNFalpha), and brain-derived neurotrophic factor (BDNF) 
      among selective serotonin reuptake inhibitor (SSRI)- or serotonin noradrenaline 
      reuptake inhibitor (SNRI)-responsive depressed patients (n=31), SSRI- or 
      SNRI-refractory depressed patients (n=20), and healthy controls (n=30). The 
      plasma levels of IL-6 and TNF-alpha were significantly higher in depressed 
      patients than in healthy controls. Treatment with antidepressants significantly 
      reduced plasma levels of IL-6 and TNF-alpha. In addition, the plasma IL-6 level, 
      but not the plasma TNF-alpha level, was higher in SSRI-refractory than 
      SSRI-responsive depressed patients, and higher in SNRI-refractory than 
      SNRI-responsive depressed patients. On the other hand, the plasma BDNF level was 
      significantly lower in depressed patients than in healthy controls, whereas no 
      difference was found in plasma BDNF levels between SSRI-responsive and 
      -refractory depressed patients or between SNRI-responsive and -refractory 
      depressed patients. These results suggest that higher plasma IL-6 activity is 
      associated with the refractoriness of depression, and plasma IL-6 levels might be 
      a predictor for response to SSRIs or SNRI.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, School of Medicine, University of Occupational and 
      Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan. 
      yoshi621@med.uoeh-u.ac.jp
FAU - Hori, Hikaru
AU  - Hori H
FAU - Ikenouchi-Sugita, Atsuko
AU  - Ikenouchi-Sugita A
FAU - Umene-Nakano, Wakako
AU  - Umene-Nakano W
FAU - Ueda, Nobuhisa
AU  - Ueda N
FAU - Nakamura, Jun
AU  - Nakamura J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090328
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Depression/*blood/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
MH  - Statistics as Topic
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2009/04/01 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/04/01 09:00
PHST- 2009/01/09 00:00 [received]
PHST- 2009/03/04 00:00 [revised]
PHST- 2009/03/22 00:00 [accepted]
PHST- 2009/04/01 09:00 [entrez]
PHST- 2009/04/01 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - S0278-5846(09)00096-7 [pii]
AID - 10.1016/j.pnpbp.2009.03.020 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):722-6. doi: 
      10.1016/j.pnpbp.2009.03.020. Epub 2009 Mar 28.