PMID- 19335934
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20220311
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 39
IP  - 11
DP  - 2009 Nov
TI  - The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in 
      healthy humans: incremental support for a genetic risk factor for depression.
PG  - 1831-9
LID - 10.1017/S0033291709005509 [doi]
AB  - BACKGROUND: The role of the brain-derived neurotrophic factor (BDNF) in the 
      pathogenesis of affective disorders such as depression has been controversial. 
      Mounting evidence comes from structural imaging, that the functional BDNF 
      Val66Met polymorphism influences the hippocampal volume with carriers of the 
      66Met allele (Val/Met and Met/Met group) having smaller hippocampi. Given that 
      stress-induced atrophy of the hippocampus is associated with the pathogenesis of 
      affective disorders, the functional BDNF Val66Met polymorphism could be an 
      incremental risk factor. METHOD: Eighty-seven healthy Caucasian participants 
      underwent structural imaging and were genotyped for the BDNF Val66Met 
      polymorphism. Data were analysed by means of voxel-based morphometry (VBM). 
      RESULTS: Region of interest (ROI) analyses revealed an association between the 
      66Met allele and smaller parahippocampal volumes and a smaller right amygdala. In 
      addition, the whole-brain analysis showed that the thalamus, fusiformus gyrus and 
      several parts of the frontal gyrus were smaller in 66Met allele carriers. 
      CONCLUSIONS: This study demonstrates that the impact of the BDNF Val66Met 
      polymorphism is not confined to the hippocampus but also extends to the 
      parahippocampal gyrus and the amygdala.
FAU - Montag, C
AU  - Montag C
AD  - Department of Psychology, Laboratory of Neurogenetics, University of Bonn, 
      Germany. christian.montag@uni-bonn-diff.de
FAU - Weber, B
AU  - Weber B
FAU - Fliessbach, K
AU  - Fliessbach K
FAU - Elger, C
AU  - Elger C
FAU - Reuter, M
AU  - Reuter M
LA  - eng
PT  - Journal Article
DEP - 20090401
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Amygdala/*pathology
MH  - Atrophy
MH  - Brain/pathology
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder/diagnosis/*genetics
MH  - Dominance, Cerebral/genetics
MH  - Female
MH  - Frontal Lobe/pathology
MH  - Genetic Carrier Screening
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Hippocampus/pathology
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Parahippocampal Gyrus/*pathology
MH  - Polymorphism, Genetic/*genetics
MH  - Reference Values
MH  - Risk Factors
MH  - Thalamus/pathology
MH  - Young Adult
EDAT- 2009/04/02 09:00
MHDA- 2010/02/18 06:00
CRDT- 2009/04/02 09:00
PHST- 2009/04/02 09:00 [entrez]
PHST- 2009/04/02 09:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - S0033291709005509 [pii]
AID - 10.1017/S0033291709005509 [doi]
PST - ppublish
SO  - Psychol Med. 2009 Nov;39(11):1831-9. doi: 10.1017/S0033291709005509. Epub 2009 
      Apr 1.