PMID- 19336249
OWN - NLM
STAT- MEDLINE
DCOM- 20090824
LR  - 20211020
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 161
IP  - 3
DP  - 2009 Jul 7
TI  - Convergent, not serial, striatal and pallidal circuits regulate opioid-induced 
      food intake.
PG  - 718-33
LID - 10.1016/j.neuroscience.2009.03.057 [doi]
AB  - Mu opioid receptor (MOR) signaling in the nucleus accumbens (NAcc) elicits marked 
      increases in the consumption of palatable tastants. However, the mechanism and 
      circuitry underlying this effect are not fully understood. Multiple downstream 
      target regions have been implicated in mediating this effect but the role of the 
      ventral pallidum (VP), a primary target of NAcc efferents, has not been well 
      defined. To probe the mechanisms underlying increased consumption, we identified 
      behavioral changes in rats' licking patterns following NAcc MOR stimulation. 
      Because the temporal structure of licking reflects the physiological substrates 
      modulating consumption, these measures provide a useful tool in dissecting the 
      cause of increased consumption following NAcc MOR stimulation. Next, we used a 
      combination of pharmacological inactivation and lesions to define the role of the 
      VP in hyperphagia following infusion of the MOR-specific agonist [D-Ala2, 
      N-MePhe4, Gly-ol]-enkephalin (DAMGO) into the NAcc. In agreement with previous 
      studies, results from lick microstructure analysis suggest that NAcc MOR 
      stimulation augments intake through a palatability-driven mechanism. Our results 
      also demonstrate an important role for the VP in normal feeding behavior: 
      pharmacological inactivation of the VP suppresses baseline and NAcc DAMGO-induced 
      consumption. However, this interaction does not occur through a serial circuit 
      requiring direct projections from the NAcc to the VP. Rather, our results 
      indicate that NAcc and VP circuits converge on a common downstream target that 
      regulates food intake.
FAU - Taha, S A
AU  - Taha SA
AD  - Department of Physiology, University of Utah School of Medicine, Salt Lake City, 
      UT 84108, USA. s.taha@utah.edu
FAU - Katsuura, Y
AU  - Katsuura Y
FAU - Noorvash, D
AU  - Noorvash D
FAU - Seroussi, A
AU  - Seroussi A
FAU - Fields, H L
AU  - Fields HL
LA  - eng
GR  - R21 MH082325/MH/NIMH NIH HHS/United States
GR  - R21 MH082325-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090329
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (GABA Agonists)
RN  - 0 (Neurotoxins)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Opioid, mu)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 2763-96-4 (Muscimol)
RN  - F6F0HK1URN (Quinolinic Acid)
SB  - IM
MH  - Animals
MH  - Catheterization
MH  - Eating/drug effects/*physiology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage
MH  - Feeding Behavior/drug effects/physiology
MH  - GABA Agonists/administration & dosage
MH  - Globus Pallidus/drug effects/*physiology
MH  - Hyperphagia/chemically induced/physiopathology
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Muscimol/administration & dosage
MH  - Neural Pathways/drug effects/physiology
MH  - Neurotoxins/toxicity
MH  - Neurotransmitter Agents/administration & dosage
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Quinolinic Acid/toxicity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Opioid, mu/agonists/*metabolism
MH  - Time Factors
PMC - PMC2699890
MID - NIHMS106551
EDAT- 2009/04/02 09:00
MHDA- 2009/08/25 09:00
PMCR- 2010/07/07
CRDT- 2009/04/02 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2009/02/23 00:00 [revised]
PHST- 2009/03/21 00:00 [accepted]
PHST- 2009/04/02 09:00 [entrez]
PHST- 2009/04/02 09:00 [pubmed]
PHST- 2009/08/25 09:00 [medline]
PHST- 2010/07/07 00:00 [pmc-release]
AID - S0306-4522(09)00467-9 [pii]
AID - 10.1016/j.neuroscience.2009.03.057 [doi]
PST - ppublish
SO  - Neuroscience. 2009 Jul 7;161(3):718-33. doi: 10.1016/j.neuroscience.2009.03.057. 
      Epub 2009 Mar 29.