PMID- 19336781
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20240317
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 194
IP  - 4
DP  - 2009 Apr
TI  - Molecular differentiation of schizoaffective disorder from schizophrenia using 
      BDNF haplotypes.
PG  - 313-8
LID - 10.1192/bjp.bp.108.050401 [doi]
AB  - BACKGROUND: Allelic variation in the gene encoding brain-derived neurotrophic 
      factor (BDNF) has been associated with affective disorders, but generally not 
      schizophrenia. Brain-derived neurotrophic factor variants may help clarify the 
      status of schizoaffective disorder. AIMS: To test the hypothesis that BDNF 
      haplotypes are associated with psychiatric illness marked by a prominent 
      affective component. METHOD: Frequencies of a 5-marker BDNF haplotype were 
      examined in 600 White participants across four diagnostic categories and healthy 
      controls. RESULTS: Individuals with schizoaffective disorder and other affective 
      disorders were significantly more likely to carry two copies of the most common 
      BDNF haplotype (containing the valine allele of the Val66Met polymorphism) 
      compared with healthy volunteers. Moreover, when compared with people with 
      schizophrenia, individuals with schizoaffective disorder were significantly more 
      likely to carry two copies of the common haplotype. CONCLUSIONS: To our 
      knowledge, this is the first candidate gene study to demonstrate association with 
      schizoaffective disorder but not schizophrenia. Variation in the BDNF gene may be 
      associated with the clinical phenotype of affective dysregulation across several 
      DSM-IV diagnostic categories.
FAU - Lencz, Todd
AU  - Lencz T
AD  - The Zucker Hillside Hospital, Psychiatry Research, 75-59 263rd Street, Glen Oaks, 
      New York 11004, USA. lencz@lij.edu
FAU - Lipsky, Robert H
AU  - Lipsky RH
FAU - DeRosse, Pamela
AU  - DeRosse P
FAU - Burdick, Katherine E
AU  - Burdick KE
FAU - Kane, John M
AU  - Kane JM
FAU - Malhotra, Anil K
AU  - Malhotra AK
LA  - eng
GR  - K23 MH001760/MH/NIMH NIH HHS/United States
GR  - K01 MH65580/MH/NIMH NIH HHS/United States
GR  - K99 MH086756/MH/NIMH NIH HHS/United States
GR  - M01 RR018535/RR/NCRR NIH HHS/United States
GR  - K01 MH065580/MH/NIMH NIH HHS/United States
GR  - R00 MH086756-03/MH/NIMH NIH HHS/United States
GR  - K23 MH01760/MH/NIMH NIH HHS/United States
GR  - P30 MH060575/MH/NIMH NIH HHS/United States
GR  - K01 MH065580-05/MH/NIMH NIH HHS/United States
GR  - P30 MH074543-04/MH/NIMH NIH HHS/United States
GR  - P30 MH060575-05/MH/NIMH NIH HHS/United States
GR  - M01 RR18535/RR/NCRR NIH HHS/United States
GR  - P30 MH074543/MH/NIMH NIH HHS/United States
GR  - R00 MH086756/MH/NIMH NIH HHS/United States
GR  - M01 RR018535-06/RR/NCRR NIH HHS/United States
GR  - K99 MH086756-01/MH/NIMH NIH HHS/United States
GR  - K23 MH001760-05/MH/NIMH NIH HHS/United States
GR  - K99 MH086756-02/MH/NIMH NIH HHS/United States
GR  - P30 MH60575/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
RN  - HG18B9YRS7 (Valine)
SB  - IM
CIN - Br J Psychiatry. 2009 Aug;195(2):179; author reply 179-80. PMID: 19648556
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Markers
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Mood Disorders/*genetics/physiopathology
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/*genetics/physiopathology
MH  - Valine/*genetics
PMC - PMC2664969
MID - NIHMS78001
EDAT- 2009/04/02 09:00
MHDA- 2009/08/04 09:00
PMCR- 2010/04/01
CRDT- 2009/04/02 09:00
PHST- 2009/04/02 09:00 [entrez]
PHST- 2009/04/02 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - S0007125000249386 [pii]
AID - 0313 [pii]
AID - 10.1192/bjp.bp.108.050401 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2009 Apr;194(4):313-8. doi: 10.1192/bjp.bp.108.050401.