PMID- 19336895
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 32
IP  - 4
DP  - 2009 Apr
TI  - Age-dependent spatial distribution of bromodeoxyuridine-immunoreactive cells in 
      the main olfactory bulb.
PG  - 627-30
AB  - The subventricular zone (SVZ) generates an immense number of neurons, which 
      migrate to the main olfactory bulb (MOB) and differentiate into granule cells and 
      periglomerular cells in the MOB, even during adulthood. Pheromonal signals, which 
      are mainly received by the vomeronasal organ, provide specific information 
      concerning the reproductive state in a variety of mammal. Vomeronasal sensory 
      neurons project to the accessory olfactory bulb (AOB) located on the dorso-caudal 
      surface of the MOB. In the present study, bromodeoxyuridine-immunoreactive 
      (BrdU-ir) structures in the sagittal section of the MOB including the AOB of 
      young and old male rats were studied to explore the roles of newly generated 
      cells at the region near the rostral end of AOB in the MOB. The density of 
      BrdU-ir cells in the granule cell layer of the MOB of young rats was higher than 
      that of old rats. In young rats, the density of BrdU-ir cells at the region near 
      the rostral end of the AOB was higher than that at the region distant from the 
      AOB. In old rats, the density of BrdU-ir cells at the near region was lower than 
      that at the distant region. The density of BrdU-ir cells at the region near the 
      AOB in the MOB in old rats may be concerned with age-dependent changes in ability 
      of discrimination and memory of general odors and odors related to the 
      reproduction.
FAU - Honda, Noriko
AU  - Honda N
AD  - Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan.
FAU - Sakamoto, Harumi
AU  - Sakamoto H
FAU - Inamura, Kouhei
AU  - Inamura K
FAU - Kashiwayanagi, Makoto
AU  - Kashiwayanagi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Antimetabolites)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Aging/*physiology/*psychology
MH  - Animals
MH  - Antimetabolites/*pharmacology
MH  - Bromodeoxyuridine/*pharmacology
MH  - Immunohistochemistry
MH  - Male
MH  - Odorants
MH  - Olfactory Bulb/*cytology/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/drug effects/physiology
MH  - Thymidine
EDAT- 2009/04/02 09:00
MHDA- 2009/05/13 09:00
CRDT- 2009/04/02 09:00
PHST- 2009/04/02 09:00 [entrez]
PHST- 2009/04/02 09:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
AID - JST.JSTAGE/bpb/32.627 [pii]
AID - 10.1248/bpb.32.627 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2009 Apr;32(4):627-30. doi: 10.1248/bpb.32.627.