PMID- 19337411
OWN - NLM
STAT- MEDLINE
DCOM- 20090505
LR  - 20231103
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 3
IP  - 4
DP  - 2008
TI  - Nanomembrane-driven co-elution and integration of active chemotherapeutic and 
      anti-inflammatory agents.
PG  - 425-33
AB  - The release of therapeutic drugs from the surface of implantable devices is 
      instrumental for the reduction of medical costs and toxicity associated with 
      systemic administration. In this study we demonstrate the triblock 
      copolymer-mediated deposition and release of multiple therapeutics from a single 
      thin film at the air-water interface via Langmuir-Blodgett deposition. The dual 
      drug elution of dexamethasone (Dex) and doxorubicin hydrochloride (Dox) from the 
      thin film is measured by response in the RAW 264.7 murine macrophage cell line. 
      The integrated hydrophilic and hydrophobic components of the polymer structure 
      allows for the creation of hybrids of the copolymer and the hydrophobic Dex and 
      the hydrophilic Dox. Confirmation of drug release and functionality was 
      demonstrated via suppression of the interleukin 6 (IL-6) and tumor necrosis 
      factor alpha (TNFalpha) inflammatory cytokines (Dex), as well as TUNEL staining 
      and DNA fragmentation analysis (Dox). The inherent biocompatibility of the 
      copolymeric material is further demonstrated by the lack of inflammation and 
      apoptosis induction in cells grown on the copolymer films. Thus a layer-by-layer 
      anchored deposition of an anti-inflammatory and chemotherapeutic functionalized 
      copolymer film is able to localize drug dosage to the surface of a medical 
      device, all with an innate material thickness of 4 nm per layer.
FAU - Pierstorff, Erik
AU  - Pierstorff E
AD  - Department of Biomedical Engineering, Robert R McCormick School of Engineering 
      and Applied Science, Feinberg School of Medicine, Northwestern University, 
      Evanston, IL, USA. e-pierstorff@northwestern.edu
FAU - Ho, Dean
AU  - Ho D
LA  - eng
GR  - U54 A1065358/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Cytokines)
RN  - 0 (Drug Carriers)
RN  - 0 (Drug Combinations)
RN  - 0 (Membranes, Artificial)
SB  - IM
MH  - Absorption
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage/chemistry
MH  - Antibiotics, Antineoplastic/administration & dosage/chemistry
MH  - Cell Line
MH  - Chemistry, Pharmaceutical/*methods
MH  - Cytokines/*immunology
MH  - Drug Carriers/administration & dosage/*chemistry
MH  - Drug Combinations
MH  - Macrophages/drug effects/*immunology
MH  - Materials Testing
MH  - *Membranes, Artificial
MH  - Mice
MH  - Nanomedicine/methods
MH  - Nanostructures/*chemistry/therapeutic use
PMC - PMC2636579
OTO - NOTNLM
OT  - chemotherapy
OT  - co-elution
OT  - combinatorial therapy
OT  - drug delivery
OT  - inflammation
OT  - nanomedicine
EDAT- 2008/01/01 00:00
MHDA- 2009/05/06 09:00
PMCR- 2009/04/01
CRDT- 2009/04/02 09:00
PHST- 2009/04/02 09:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2009/05/06 09:00 [medline]
PHST- 2009/04/01 00:00 [pmc-release]
AID - ijn-3-425 [pii]
AID - 10.2147/ijn.s4035 [doi]
PST - ppublish
SO  - Int J Nanomedicine. 2008;3(4):425-33. doi: 10.2147/ijn.s4035.