PMID- 19337469 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110518 LR - 20211020 IS - 1176-6328 (Print) IS - 1178-2021 (Electronic) IS - 1176-6328 (Linking) VI - 4 IP - 6 DP - 2008 Dec TI - Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes. PG - 1277-81 AB - In the present study, the authors reported on a case in neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) with irreversible organic brain changes. The authors also longitudinally investigated serum brain-derived neurotrophic factor (BDNF) levels in the patient. We found that serum BDNF levels in the NPSLE patient with irreversible organic brain change were consistently low, independent of the severity of psychiatric symptoms. Thus, the longitudinal measurement of serum BDNF levels might be useful in predicting the prognosis of NPSLE. FAU - Ikenouchi-Sugita, Atsuko AU - Ikenouchi-Sugita A AD - Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan. FAU - Yoshimura, Reiji AU - Yoshimura R FAU - Ueda, Nobuhisa AU - Ueda N FAU - Kodama, Yuki AU - Kodama Y FAU - Umene-Nakano, Wakako AU - Umene-Nakano W FAU - Nakamura, Jun AU - Nakamura J LA - eng PT - Case Reports PL - New Zealand TA - Neuropsychiatr Dis Treat JT - Neuropsychiatric disease and treatment JID - 101240304 PMC - PMC2646658 OTO - NOTNLM OT - brain-derived neurotrophic factor OT - neuropsychiatric syndrome of systemic lupus erythematosus OT - organic brain change EDAT- 2009/04/02 09:00 MHDA- 2009/04/02 09:01 PMCR- 2009/04/01 CRDT- 2009/04/02 09:00 PHST- 2009/04/02 09:00 [entrez] PHST- 2009/04/02 09:00 [pubmed] PHST- 2009/04/02 09:01 [medline] PHST- 2009/04/01 00:00 [pmc-release] AID - ndt-4-1277 [pii] AID - 10.2147/ndt.s4259 [doi] PST - ppublish SO - Neuropsychiatr Dis Treat. 2008 Dec;4(6):1277-81. doi: 10.2147/ndt.s4259.