PMID- 19337907
OWN - NLM
STAT- MEDLINE
DCOM- 20090617
LR  - 20131121
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Linking)
VI  - 35
IP  - 3
DP  - 2009 Apr
TI  - Effects of combined bacille Calmette-Guerin and dehydroepiandrosterone treatment 
      on established asthma in mice.
PG  - 250-61
LID - 10.1080/01902140802626656 [doi]
AB  - Both bacille Calmette-Guerin (BCG) and dehydroepiandrosterone induce Th1 immune 
      responses and suppress Th2 allergic reactions. To investigate whether a combined 
      administration of BCG and dehydroepiandrosterone treat asthma more effectively, 
      BALB/c mice (n = 8 per group) with established airway hyper-responsiveness were 
      treated with BCG and/or dehydroepiandrosterone. Combined treatment with 2 x 10(5) 
      colony-forming units (CFUs) of BCG and 0.01% dehydroepiandrosterone was the most 
      effective one at suppressing eosinophilia in bronchoalveolar lavage fluids. In 
      addition, this combination also was better at suppressing hypersensitivity as 
      compared to BCG alone (13.7 +/- 4.0- versus 3.6 +/- 0.5-fold increase in the 
      sensitivity index; P < .05) in male mice. Similarly, the effect of the combined 
      treatment was superior to that of individual treatments at decreasing the serum 
      ovalbumin-specific immunoglobulin E (IgE) level. However, the addition of 0.1% 
      dehydroepiandrosterone to BCG significantly decreased the efficacy of BCG on 
      hypersensitivity in female mice. In male mice, the suppressive effect of the 
      treatments on hypersensitivity tended to be lower, and the baseline 
      interferon-gamma /interleukin-5 (IFN-gamma /IL-5) ratio in the splenocyte 
      supernatant was significantly higher as compared to female mice. In conclusion, 
      treatment with an appropriate combination of BCG and dehydroepiandrosterone had 
      additive therapeutic effects on mice with established asthma. Androgens in males 
      and dehydroepiandrosterone overdose might reduce the efficacy of BCG.
FAU - Lin, Xiang-Hua
AU  - Lin XH
AD  - Department of Medicine, Chonnam National University Graduate School, Gwangju, 
      Republic of Korea.
FAU - Choi, Inseon S
AU  - Choi IS
FAU - Koh, Young-Ah
AU  - Koh YA
FAU - Cui, Yong
AU  - Cui Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 459AG36T1B (Dehydroepiandrosterone)
SB  - IM
MH  - Animals
MH  - Asthma/*therapy
MH  - Biological Therapy/*methods
MH  - Bronchoalveolar Lavage Fluid
MH  - Combined Modality Therapy
MH  - Dehydroepiandrosterone/immunology/*pharmacology/therapeutic use
MH  - Eosinophilia/drug therapy
MH  - Female
MH  - Immunity
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Mycobacterium bovis/immunology
MH  - Sex Factors
MH  - Spleen/cytology
MH  - Treatment Outcome
EDAT- 2009/04/02 09:00
MHDA- 2009/06/18 09:00
CRDT- 2009/04/02 09:00
PHST- 2009/04/02 09:00 [entrez]
PHST- 2009/04/02 09:00 [pubmed]
PHST- 2009/06/18 09:00 [medline]
AID - 910059264 [pii]
AID - 10.1080/01902140802626656 [doi]
PST - ppublish
SO  - Exp Lung Res. 2009 Apr;35(3):250-61. doi: 10.1080/01902140802626656.